Universidade Estadual de Ponta Grossa - Departamento de Medicina - Ponta Grossa (PR), Brazil.
Faculdade Evangélica Mackenzie - Departamento de Oncologia - Curitiba (PR), Brazil.
Acta Cir Bras. 2024 Apr 15;39:e392124. doi: 10.1590/acb392124. eCollection 2024.
To evaluate the effects of curcumin supplementation on abdominal surgical wound healing in rats using clinical, histological, and hematological parameters.
Forty Wistar rats were randomly divided into two groups: the curcumin group, and the control group. The curcumin group received, in addition to water and standard feed, curcumin via gavage at the dose of 200 mg/kg for seven days preceding and seven days following surgery. The control group received only water and standard feed. Both groups underwent median laparotomy and left colotomy. On the eighth postoperative day, the groups were euthanized, and the left colon was resected for histological analysis.
In the preoperative evaluation, there was a significant decrease in the mean C-reactive protein levels in the curcumin group (0.06) compared to the control group (0.112) (p = 0.0001). In the postoperative wound healing assessment, a significant decrease was observed in inflammatory infiltrate (p = 0.0006) and blood vessel count (p = 0.0002) in the curcumin group compared to the control group.
Curcumin supplementation was able to significantly reduce inflammatory parameters in both pre-and post-operative phases of abdominal surgical wounds in rats.
使用临床、组织学和血液学参数评估姜黄素补充剂对大鼠腹部外科伤口愈合的影响。
将 40 只 Wistar 大鼠随机分为两组：姜黄素组和对照组。姜黄素组除了给予水和标准饲料外，还在术前 7 天和术后 7 天通过灌胃给予 200mg/kg 的姜黄素。对照组仅给予水和标准饲料。两组均进行中腹部切开术和左结肠切开术。术后第 8 天，两组均安乐死，并切除左结肠进行组织学分析。
在术前评估中，与对照组（0.112）相比，姜黄素组的 C 反应蛋白水平（0.06）显著降低（p=0.0001）。在术后伤口愈合评估中，与对照组相比，姜黄素组的炎症浸润（p=0.0006）和血管计数（p=0.0002）均显著减少。
姜黄素补充剂能够显著降低大鼠腹部外科伤口在术前和术后两个阶段的炎症参数。
