Ministry of Health of Russia, Research Institute of Biotechnology "Biotech", Samara State Medical University, 443099 Samara, Russia.
Cells. 2023 Feb 24;12(5):731. doi: 10.3390/cells12050731.
The aim of the article was to develop an innovative method for the study of cell proliferation based on the information-thermodynamic approach, including the mathematical ratio-the entropy of cell proliferation and an algorithm for the calculation of fractal dimension of the cellular structure. Approbation of this method with pulsed electromagnetic impact on culture in vitro was implemented. It is shown on the basis of experimental data that the organized cellular structure of juvenile human fibroblasts is a fractal. The method makes it possible to determine the stability of the effect on cell proliferation. The prospects for the application of the developed method are discussed.
本文旨在基于信息热力学方法，包括细胞增殖的熵与细胞结构分形维数的计算算法这两个数学比值，开发一种用于研究细胞增殖的创新方法。本文通过体外培养脉冲电磁场冲击的实验对该方法进行了验证。基于实验数据，本文表明，幼年人类成纤维细胞的有组织细胞结构是分形的。该方法可以确定对细胞增殖的影响的稳定性。本文还讨论了所开发方法的应用前景。
