Center for Occupational and Environmental Health, University of California, Irvine, CA 92617, USA.
Office of Public Health Studies, Thompson School of Social Work & Public Health, University of Hawaii, Mānoa, Honolulu, HI 96822, USA.
Int J Environ Res Public Health. 2023 Feb 27;20(5):4217. doi: 10.3390/ijerph20054217.
Low back pain and depression have been globally recognized as key public health problems and they are considered co-morbid conditions. This study explores both cross-sectional and longitudinal comorbid associations between back pain and major depression in the adult population in the United States. We used data from the Midlife in the United States survey (MIDUS), linking MIDUS II and III with a sample size of 2358. Logistic regression and Poisson regression models were used. The cross-sectional analysis showed significant associations between back pain and major depression. The longitudinal analysis indicated that back pain at baseline was prospectively associated with major depression at follow-up (PR 1.96, CI: 1.41, 2.74), controlling for health behavioral and demographic variables. Major depression at baseline was also prospectively associated with back pain at follow-up (PR 1.48, CI: 1.04, 2.13), controlling for a set of related confounders. These findings of a bidirectional comorbid association fill a gap in the current understanding of these comorbid conditions and could have clinical implications for the management and prevention of both depression and low back pain.
腰痛和抑郁症已被全球公认为主要的公共卫生问题，它们被认为是共病状态。本研究探讨了美国成年人中腰痛与重度抑郁症之间的横断面和纵向共病关联。我们使用了来自美国中年调查（MIDUS）的数据，将 MIDUS II 和 III 联系起来，样本量为 2358 人。使用逻辑回归和泊松回归模型进行分析。横断面分析显示，腰痛与重度抑郁症之间存在显著关联。纵向分析表明，基线时的腰痛与随访时的重度抑郁症有前瞻性关联（PR 1.96，CI：1.41，2.74），控制了健康行为和人口统计学变量。基线时的重度抑郁症也与随访时的腰痛有前瞻性关联（PR 1.48，CI：1.04，2.13），控制了一组相关混杂因素。这些双向共病关联的发现填补了当前对这些共病状态理解的空白，对抑郁症和腰痛的管理和预防具有临床意义。
