Neurovascular Research Laboratory, Faculty of Life Sciences and Education, University of South Wales, Pontypridd, UK.
Exp Physiol. 2024 Apr;109(4):474-483. doi: 10.1113/EP091177. Epub 2024 Feb 17.
Cognitive decline and spinal pain (back pain [BP] and neck pain [NP]) represent a major public health challenge, yet the potential relationship between them remains elusive. A retrospective analysis of the Longitudinal Study of Ageing Danish Twins was performed to determine any potential relationships between BP/NP and cognitive function adjusting for age, sex, educational and socioeconomic status. A total of 4731 adults (2788 females/1943 males) aged 78 ± 6 (SD) years were included in the analysis. We observed a 1-month prevalence of 25% with BP, 21% with NP and 11% for combined BP/NP. While there were no differences in cognition scores for males and females reporting combined BP/NP, compared to those without combined BP/NP (34.38 points [95% confidence interval (CI) = 31.88, 36.88] vs. 35.72 points [95% CI = 35.19, 36.26]; P = 0.180; and 35.72 points [95% CI = 35.19, 36.26] vs. 35.85 points [95% CI = 35.39, 36.31]; P = 0.327; for male and females, respectively), an adjusted analysis revealed that males with combined BP/NP presented with lower cognitive scores compared to males without combined BP/NP (81.26 points [95% CI = 73.80, 88.72] vs. 79.48 points [95% CI = 70.31, 88.66]; P = 0.043). The findings of this hypothesis-generating study may highlight a potential sex-specific association between spinal pain and later-life neurodegeneration.
认知能力下降和脊柱疼痛（背痛[BP]和颈痛[NP]）是一个主要的公共健康挑战，但它们之间的潜在关系仍然难以捉摸。对丹麦双胞胎纵向老龄化研究进行了回顾性分析，以确定在调整年龄、性别、教育和社会经济状况后，BP/NP 与认知功能之间的任何潜在关系。共纳入 4731 名年龄 78 ± 6（SD）岁的成年人（女性 2788 人，男性 1943 人）。我们观察到，BP 的 1 个月患病率为 25%，NP 为 21%，BP/NP 合并患病率为 11%。虽然报告 BP/NP 合并症的男性和女性的认知评分与没有 BP/NP 合并症的男性和女性没有差异（34.38 分[95%置信区间（CI）=31.88, 36.88]与 35.72 分[95% CI=35.19, 36.26]; P=0.180; 和 35.72 分[95% CI=35.19, 36.26]与 35.85 分[95% CI=35.39, 36.31]; P=0.327; 分别为男性和女性），但调整后的分析显示，与没有 BP/NP 合并症的男性相比，有 BP/NP 合并症的男性认知评分较低（81.26 分[95% CI=73.80, 88.72]与 79.48 分[95% CI=70.31, 88.66]; P=0.043）。这项产生假说的研究结果可能强调了脊柱疼痛与晚年神经退行性变之间潜在的性别特异性关联。
