Paus E, Fosså S D, Risberg T, Nustad K
Central Laboratory, Norwegian Radium Hospital, Oslo.
Br J Urol. 1987 Jun;59(6):572-7. doi: 10.1111/j.1464-410x.1987.tb04880.x.
Human chorionic gonadotrophin (HCG) was measured in sera from seminoma patients by an immunoassay which recognised both free beta-chains and intact HCG molecules. This seemed to increase the sensitivity of the assay without affecting its specificity. The HCG values were correlated to the clinical course in 151 patients. Pre-orchiectomy samples were assayed in 57 patients. Elevated pre-operative HCG levels were found in 15 of 38 patients (39%) in stage I and in 13 of 19 patients (68%) in stages II to IV. After orchiectomy the HCG values were normal in 114 of 115 patients in stage I and elevated in 13 of 36 patients (36%) in stages II to IV. Relapses were observed more often in stage II to IV patients who produced HCG at the time of diagnosis than in non-producers (3 of 13 patients versus 1 of 23 patients). In 7 of 11 relapses the serum HCG was elevated. HCG positive relapses were seen in patients both with and without initially elevated serum HCG.
采用一种能识别游离β链和完整人绒毛膜促性腺激素（HCG）分子的免疫测定法，对精原细胞瘤患者血清中的HCG进行检测。这似乎提高了检测的灵敏度，而不影响其特异性。对151例患者的HCG值与临床病程进行了相关性分析。对57例患者的睾丸切除术前样本进行了检测。在I期的38例患者中，有15例（39%）术前HCG水平升高；在II至IV期的19例患者中，有13例（68%）术前HCG水平升高。睾丸切除术后，I期的115例患者中有114例HCG值正常，II至IV期的36例患者中有13例（36%）HCG值升高。与诊断时不产生HCG的II至IV期患者相比，诊断时产生HCG的患者复发更为常见（13例患者中有3例复发，而23例患者中有1例复发）。在11例复发患者中，有7例血清HCG升高。血清HCG最初升高和未升高的患者均出现了HCG阳性复发。
