Chen Boxu, Sun Xiaohao, Liu Debao, Tian Hua, Gao Jingjun
School of Materials Science and Engineering, Tianjin University of Technology, Tianjin, 300384, China.
National Demonstration Center for Experimental Function Materials Education, Tianjin University of Technology, Tianjin, 300384, China.
J Mech Behav Biomed Mater. 2023 May;141:105763. doi: 10.1016/j.jmbbm.2023.105763. Epub 2023 Mar 7.
Zinc alloy porous scaffolds are expected to be the next generation of degradable orthopedic implants attributed to their suitable degradation rate. However, a few studies have thoroughly investigated its applicable preparation method and functionality as an orthopedic implant. This study fabricated Zn-1Mg porous scaffolds with triply periodic minimal surface (TPMS) structure by a novel method combining VAT photopolymerization and casting. As-built porous scaffolds displayed fully connected pore structures with controllable topology. The manufacturability, mechanical properties, corrosion behaviors, biocompatibility, and antimicrobial performance of the bioscaffolds with pore sizes of 650 μm, 800 μm, and 1040 μm were investigated, and then compared and discussed with each other. In simulations, the mechanical behaviors of porous scaffolds exhibited the same tendency as the experiments. In addition, the mechanical properties of porous scaffolds as a function of degradation time were studied through a 90-day immersion experiment, which can provide a new option for analyzing the mechanical properties of porous scaffolds implanted in vivo. The G06 scaffold with lower pore size presented better mechanical properties before and after degradation compared with G10. The G06 scaffold with the pore size of 650 μm revealed good biocompatibility and antibacterial properties, which makes it possible to be one of the candidates for orthopedic implants.
锌合金多孔支架因其合适的降解速率有望成为下一代可降解骨科植入物。然而，很少有研究全面探究其作为骨科植入物的适用制备方法和功能。本研究通过一种结合立体光刻和铸造的新方法制备了具有三重周期极小曲面（TPMS）结构的Zn-1Mg多孔支架。制成的多孔支架呈现出具有可控拓扑结构的完全连通孔隙结构。研究了孔径为650μm、800μm和1040μm的生物支架的可制造性、力学性能、腐蚀行为、生物相容性和抗菌性能，然后相互进行了比较和讨论。在模拟中，多孔支架的力学行为与实验表现出相同的趋势。此外，通过90天的浸泡实验研究了多孔支架力学性能随降解时间的变化，这可为分析体内植入多孔支架的力学性能提供新的选择。与G10相比，孔径较小的G06支架在降解前后均表现出更好的力学性能。孔径为650μm的G06支架具有良好的生物相容性和抗菌性能，这使其有可能成为骨科植入物的候选材料之一。
