Specialization Course in Oral Implantology, Faculdade CTA, São Paulo, SP, Brazil.
Graduate Dentistry Program, Ibirapuera University, São Paulo, SP, Brazil.
Oral Maxillofac Surg. 2024 Mar;28(1):39-49. doi: 10.1007/s10006-023-01149-3. Epub 2023 Mar 13.
Ozone is a potent antioxidant agent which presents an important antimicrobial action and many other biological effects. Although ozone therapy has been widely described and summarized in several other Dentistry areas recently, the studies concerning Dental Implantology have not been systematically compiled and evaluated. Thus, the present study aimed to evaluate the effectiveness of ozone therapy in dental implant procedures.
MEDLINE (via PUBMED), Cochrane Central Register of Controlled Trials (CENTRAL), and OpenGrey databases were searched (up to, and including, January 23, 2023) for studies in the English language. In addition, the reference lists of the articles were manually examined. Only interventional studies (controlled clinical trials, randomized or not) were considered eligible for inclusion. The risk of bias in each included study was assessed using the Cochrane tool for assessing risk of bias in randomized trials - version 2.
71 potentially eligible records were retrieved but only 5 articles were evaluated and considered eligible for inclusion. Among the studies, 2 addressed clinical situations related to implant insertion, and 3 involved pathological conditions affecting implants in function. Furthermore, only one randomized clinical trial was categorized as low risk of bias.
The adjuvant use of ozone therapy may positively affect some outcomes in Implant Dentistry, both in treating pathological conditions and conducting rehabilitation (implant installation, secondary implant stability). However, as most studies have a high risk of bias and high heterogeneity, a definitive conclusion cannot be drawn.
臭氧是一种有效的抗氧化剂，具有重要的抗菌作用和许多其他生物学效应。尽管臭氧治疗在最近的其他几个牙科领域得到了广泛的描述和总结，但关于牙科植入物的研究尚未得到系统的编译和评估。因此，本研究旨在评估臭氧治疗在牙科植入物手术中的有效性。
通过 MEDLINE（通过 PUBMED）、Cochrane 对照试验中心注册（CENTRAL）和 OpenGrey 数据库（截至 2023 年 1 月 23 日）搜索英语文献。此外，还手动检查了文章的参考文献。只有干预性研究（对照临床试验，随机或非随机）被认为符合纳入标准。使用 Cochrane 评估随机试验偏倚风险工具（版本 2）评估每个纳入研究的偏倚风险。
共检索到 71 篇可能符合条件的记录，但只有 5 篇文章被评估并认为符合纳入标准。在这些研究中，有 2 项研究涉及与植入物插入相关的临床情况，3 项研究涉及影响植入物功能的病理情况。此外，只有一项随机临床试验被归类为低偏倚风险。
臭氧治疗的辅助应用可能会对植入牙科的某些结果产生积极影响，无论是在治疗病理情况还是进行康复（植入物安装、二次植入物稳定性）方面。然而，由于大多数研究存在高偏倚风险和高度异质性，因此无法得出明确的结论。
