Shekhar Abhinav, Sikdar Chinmoy, Srivastava Shitij, Chaturvedi Anshuman, Bhatia Love K, Sarkar Debajyoti
Department of Prosthodontics, Sardar Patel Post Graduate Institute of Dental and Medical Sciences, Lucknow, IND.
Cureus. 2025 Jun 6;17(6):e85482. doi: 10.7759/cureus.85482. eCollection 2025 Jun.
Objectives The primary objective of this randomized controlled trial was to evaluate the effect of ozone therapy on postoperative pain and the healing of soft tissues in patients undergoing dental implant placement. Methods This parallel-group, randomized clinical trial enrolled 84 participants requiring delayed implant placement. Participants were allocated by a computer-generated random sequence with allocation concealment by using the sequentially numbered, opaque, sealed envelopes (SNOSE) method. In group A, following local anesthesia and standard aseptic protocols, osteotomy was performed with irrigation using ozonated saline (25 μg/mL). Medical-grade ozone gas was introduced into the osteotomy site for 30 seconds, followed by peripheral ozone injection near the surgical site. Implants were placed with a torque of 35 Ncm, and the surgical site was closed with interrupted 3-0 silk sutures. In group B, conventional implant placement was performed using standard saline irrigation, with all other surgical steps, including implant brand, torque value, and suturing technique, kept identical to the experimental group. Postoperative pain was rated based on the visual analog scale at 24 and 48 hours; soft tissue healing was rated according to the Landry healing index at seven and 14 days. Outcome assessors were blinded to the group of the subjects, and data were analyzed using appropriate statistical methods, with a significance value considered at p < 0.05. Results The ozone therapy group showed a statistically significant reduction in pain scores at 24 hours and 48 hours compared to the control group (p < 0.05). In terms of soft tissue healing, the ozone group demonstrated improved healing rates, with earlier resolution of inflammation and faster epithelialization, particularly at 14 days postoperatively. Conclusion In the case of patients who have undergone dental implant surgery, ozone therapy seems to be a very good adjunct in relieving postoperative pain and promoting the healing of soft tissues. Consequently, these findings suggest that ozone therapy may be employed for enhancing patient recovery and improving clinical outcomes in implant dentistry.
目的 本随机对照试验的主要目的是评估臭氧疗法对接受牙种植体植入患者术后疼痛及软组织愈合的影响。方法 本平行组随机临床试验纳入了84例需要延迟植入种植体的参与者。参与者通过计算机生成的随机序列，采用连续编号、不透明、密封信封（SNOSE）法进行分配隐藏。A组在局部麻醉和标准无菌操作流程后，使用臭氧生理盐水（25μg/mL）冲洗进行截骨术。将医用级臭氧气体引入截骨部位30秒，随后在手术部位附近进行外周臭氧注射。以35Ncm的扭矩植入种植体，手术部位用3-0间断丝线缝合关闭。B组采用标准生理盐水冲洗进行常规种植体植入，所有其他手术步骤，包括种植体品牌、扭矩值和缝合技术，均与试验组保持一致。术后24小时和48小时根据视觉模拟量表对疼痛进行评分；术后7天和14天根据兰德里愈合指数对软组织愈合情况进行评分。结果评估者对受试者分组情况不知情，数据采用适当的统计方法进行分析，显著性值设定为p<0.05。结果 与对照组相比，臭氧治疗组在24小时和48小时时疼痛评分有统计学显著降低（p<0.05）。在软组织愈合方面，臭氧组显示出更高的愈合率，炎症消退更早，上皮化更快，尤其是在术后14天时。结论 对于接受牙种植手术的患者，臭氧疗法似乎是缓解术后疼痛和促进软组织愈合的良好辅助手段。因此，这些研究结果表明，臭氧疗法可用于提高种植牙科患者的恢复情况并改善临床结局。
