School of Advanced Materials Science and Engineering, Sungkyunkwan University (SKKU), Suwon, 16419, Republic of Korea.
Department of Materials Science and Engineering, Center for Human-oriented Triboelectric Energy Harvesting, Yonsei University, Seoul, 03722, Republic of Korea.
Small Methods. 2023 Jun;7(6):e2201350. doi: 10.1002/smtd.202201350. Epub 2023 Mar 12.
Implantable medical devices (IMDs) provide practical approaches to monitor physiological parameters, diagnose diseases, and aid treatment. However, device installation, maintenance, and long-term implantation increase the risk of infection with conventional IMDs. Therefore, medical devices with biocompatibility, controllability, and miniaturization are highly demandable. An ultrasound-driven, biodegradable, and injectable triboelectric nanogenerator (I-TENG) is demonstrated to reduce the risks of implant-related injuries and infections. The injection can be given by subcutaneous injection with a needle to minimize the implantation incision. The stable output of I-TENG is driven by ultrasound (20 kHz, 1 W cm ), with a voltage of 356.8 mV and current of 1.02 µA during in vivo studies and an electric field of about 0.92 V mm during ex vivo experiments. The cell scratch and proliferation assays showed that the delivered electric field effectively increased cell migration and proliferation, indicating a significant potential to accelerate healing with electricity.
植入式医疗设备 (IMD) 提供了监测生理参数、诊断疾病和辅助治疗的实用方法。然而，传统 IMD 的设备安装、维护和长期植入增加了感染的风险。因此，具有生物相容性、可控性和小型化的医疗设备需求量很大。本文展示了一种超声驱动、可生物降解和可注射的摩擦纳米发电机 (I-TENG)，可降低与植入物相关的损伤和感染风险。该注射可通过皮下注射针进行，以尽量减小植入切口。在体内研究中，I-TENG 由超声 (20 kHz，1 W cm ) 稳定驱动，产生 356.8 mV 的电压和 1.02 µA 的电流，而在离体实验中产生约 0.92 V mm 的电场。细胞划痕和增殖试验表明，所施加的电场能有效促进细胞迁移和增殖，表明电刺激具有显著的加速愈合潜力。
