酒精与大麻共同使用对神经认知功能、脑结构和脑功能的影响。
The Effects of Alcohol and Cannabis Co-Use on Neurocognitive Function, Brain Structure, and Brain Function.
作者信息
Bedillion Margaret F, Blaine Sara K, Claus Eric D, Ansell Emily B
机构信息
Penn State University, Department of Biobehavioral Health, University Park, PA 16802.
Auburn University, Department of Psychological Sciences, Auburn University, AL 36849.
出版信息
Curr Behav Neurosci Rep. 2021 Dec;8(4):134-149. doi: 10.1007/s40473-021-00243-8. Epub 2021 Nov 18.
Abstract
PURPOSE OF REVIEW
Given increases in the rates of alcohol and cannabis co-use among adolescents and young adults, this review aims to summarize literature on the effects of alcohol and cannabis co-use on neurocognitive functioning, brain structure, and brain function.
RECENT FINDINGS
The limited existing studies examining concurrent, recent, and lifetime alcohol and cannabis co-use suggest effects on the brain are likely multifaceted. The majority of studies report that co-use is associated with negative outcomes such as impaired cognitive function and significant alterations in key structural and functional regions of the brain, while others report null effects of co-use compared to non-substance using control and single-substance use groups.
SUMMARY
Current studies lack a general consensus on methodology, definitions of concurrent and simultaneous use, and neuroimaging approaches, which makes it challenging to draw strong conclusions about the effects of co-use. More studies are needed to explore the effects of co-use in the context of simultaneous alcohol and cannabis use.
摘要
综述目的
鉴于青少年和青年中酒精和大麻同时使用的比率有所上升，本综述旨在总结关于酒精和大麻同时使用对神经认知功能、脑结构和脑功能影响的文献。
最新发现
现有有限的研究考察了同时、近期和终生酒精和大麻同时使用情况，结果表明对大脑的影响可能是多方面的。大多数研究报告称，同时使用与负面结果相关，如认知功能受损以及大脑关键结构和功能区域的显著改变，而其他研究报告称，与非物质使用对照组和单一物质使用组相比，同时使用没有影响。
总结
目前的研究在方法、同时使用和同步使用的定义以及神经影像学方法上缺乏普遍共识，这使得就同时使用的影响得出强有力的结论具有挑战性。需要更多研究来探讨在同时使用酒精和大麻的情况下同时使用的影响。
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