Ramos Rosemarie G, Olden Kenneth
Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.
Am J Public Health. 2008 Jun;98(6):1122-7. doi: 10.2105/AJPH.2007.120055. Epub 2008 Apr 29.
We sought to determine whether the prevalence of metabolic syndrome among US women of childbearing age (18-44 years) has increased since 1988 and to estimate its current prevalence by race/ethnicity and risk that a maternal history of select metabolic syndrome characteristics imposes on offspring.
We used survey-specific data analysis methods to examine data from the National Health and Nutrition Examination Surveys conducted from 1988 to 2004.
The prevalence of the metabolic syndrome phenotype and 2 of its clinical correlates significantly increased between 1988 and 2004 (increase for metabolic syndrome phenotype=7.6%, for obesity=13.3%, and for elevated C-reactive protein=10.6%; P < .001 for all 3). Hispanic women were more likely than were White women to possess the phenotype (P = .004). Women who reported that their mothers had been diagnosed with diabetes were more likely to possess the phenotype than those whose mothers had not been so diagnosed (odds ratio=1.9; 95% confidence interval=1.3, 2.8).
The current trends of metabolic syndrome among women of childbearing age demonstrate the need for additional rigorous investigations regarding its long-term effects in these women and their offspring.
我们试图确定自1988年以来美国育龄妇女（18 - 44岁）代谢综合征的患病率是否有所增加，并按种族/族裔估计其当前患病率，以及特定代谢综合征特征的母亲病史对后代造成的风险。
我们使用特定调查的数据分析方法来检查1988年至2004年进行的国家健康和营养检查调查的数据。
1988年至2004年间，代谢综合征表型及其两个临床相关指标的患病率显著增加（代谢综合征表型增加7.6%，肥胖增加13.3%，C反应蛋白升高增加10.6%；所有三项P <.001）。西班牙裔女性比白人女性更有可能具有该表型（P =.004）。报告其母亲被诊断患有糖尿病的女性比其母亲未被如此诊断的女性更有可能具有该表型（比值比 = 1.9；95%置信区间 = 1.3, 2.8）。
育龄妇女代谢综合征的当前趋势表明，需要对其在这些妇女及其后代中的长期影响进行更多严格的调查。
