Ahmadi Ayat, Yazdizadeh Bahareh, Doshmangir Leila, Majdzadeh Reza, Asghari Shabnam
Knowledge Utilization Research Center Tehran University of Medical Sciences Tehran Iran.
Department of Health Policy & Management Tabriz Health Services Management Research Center, School of Management & medical informatics, Tabriz University of Medical Sciences Tabriz Iran.
Campbell Syst Rev. 2022 Apr 12;18(2):e1236. doi: 10.1002/cl2.1236. eCollection 2022 Jun.
Review studies have reported on the low quality of study methodologies and poor reporting of knowledge translation (KT) interventional studies. This flaw cause the result of such studies to become misleading.
The present review is designed to evaluate the effect of methodological factors on the results of interventional studies that aimed to evaluate KT strategies at the policy level.
Bibliographic databases and grey literature databases will be searched. The retrieved studies will be recorded in Covidence. After screening titles and abstracts, the full texts of selected studies will be assessed against the inclusion criteria. Disagreements will be resolved through discussion or by consultation with a third author.
Primary studies are studies that aimed to estimate the efficacy of KT strategies to improve evidence-informed policymaking. Study participants include policymakers and the intervention is a KT strategy. The main outcome is the desired changes in policy-makers towards evidence-informed decision-making.
The main effect sizes will be expressed as standard mean difference and its variance for the main efficacy outcome of KT strategies in primary studies. Forest plot meta-analysis will be used to synthesize the effect of each group of KT strategies. The contribution of ROB to the efficacy of KT interventions will be assessed via Meta-epidemiology analysis. The overall estimate will be calculated using inverse-variance random-effects meta-analysis with a 95% confidence interval for the estimate.
综述研究报告了研究方法质量低下以及知识转化（KT）干预性研究报告不佳的情况。这一缺陷导致此类研究结果具有误导性。
本综述旨在评估方法学因素对旨在评估政策层面KT策略的干预性研究结果的影响。
将检索书目数据库和灰色文献数据库。检索到的研究将记录在Covidence中。在筛选标题和摘要后，将根据纳入标准对所选研究的全文进行评估。分歧将通过讨论或与第三位作者协商解决。
原始研究是旨在评估KT策略以改善循证决策制定效果的研究。研究参与者包括政策制定者，干预措施为KT策略。主要结果是政策制定者在循证决策方面期望的变化。
主要效应量将以标准均数差及其方差表示，用于原始研究中KT策略主要疗效结果的分析。森林图荟萃分析将用于综合每组KT策略的效果。将通过Meta流行病学分析评估研究偏倚（ROB）对KT干预效果的影响。总体估计将使用逆方差随机效应荟萃分析计算，并给出估计值的95%置信区间。
