Systematic reviews: Not always a pain.

Systematic reviews analyze the evidence surrounding a specific intervention within a population. High quality systematic reviews can help clinicians and policymakers accurately understand a treatment intervention. This article outlines the basic principles of systematic review development, including assembling a research team, defining the research question, publishing a protocol, designing and executing the search, study selection, extracting the data, assessing risk of bias, synthesizing the data and conducting a certainty assessment. In addition, we will address common pitfalls and highlight special considerations for the field of interventional pain medicine. Understanding systematic review methodology will help investigators improve their primary research and in turn, better primary literature will improve the value of high quality reviews.