• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

ERBB3介导PI3K/AKT/mTOR信号通路，改变宫颈癌中的上皮-间质转化，并预测免疫浸润结果。

ERBB3 mediates the PI3K/AKT/mTOR pathway to alter the epithelial‑mesenchymal transition in cervical cancer and predict immunity filtration outcome.

作者信息

Yang Xiaoyue, Zhu Weipei

机构信息

Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215000, P.R. China.

出版信息

Exp Ther Med. 2023 Feb 15;25(4):146. doi: 10.3892/etm.2023.11845. eCollection 2023 Apr.

DOI:10.3892/etm.2023.11845
PMID:36911370
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9995796/
Abstract

Cervical cancer is the fourth most common cancer among women worldwide, and the prognosis of advanced/recurrent cervical cancer remains poor. Metastasis and invasion of this type of cancer are closely associated with the tumor microenvironment. Studying the complex interactions between tumor progression and immune cells or stromal cells can provide new insights into treatment for patients with aggressive tumor, recurrence and drug resistance. In the present study, a bioinformatics method (Gene Expression Profiling Interactive Analysis, differentially expressed genes, Gene Ontology, Kyoto Encyclopedia of Genes and Genomes, protein-protein interactions and survival analysis) was used to explore the mRNA and protein level discrepancy gene signature of ERBB3 via the PI3K/AKT/mTOR pathway from the speculation in immuno-oncology and experimental verification of different cervical cancer cell lines. The high expression of ERBB3 in cervical cancer tissues (especially HPV-positive and adenocarcinoma-related) promoted the activation of the PI3K/AKT/mTOR pathway. The increased expression of MMP9 changed the macrophage infiltration in the tumor microenvironment and affected prognosis of patients with cervical cancer. In conclusion, the present study identified 14 EMT-related genes and 30 genes involved in the PI3K/AKT/mTOR pathway in cervical cancer, and they might provide novel clues for future treatment. The MMP family may be a notable factor associated with tumor cells and immune cells.

摘要

宫颈癌是全球女性中第四大常见癌症，晚期/复发性宫颈癌的预后仍然很差。这类癌症的转移和侵袭与肿瘤微环境密切相关。研究肿瘤进展与免疫细胞或基质细胞之间的复杂相互作用可为侵袭性肿瘤、复发和耐药患者的治疗提供新见解。在本研究中，运用了一种生物信息学方法（基因表达谱交互分析、差异表达基因、基因本体论、京都基因与基因组百科全书、蛋白质-蛋白质相互作用和生存分析），从免疫肿瘤学的推测和对不同宫颈癌细胞系的实验验证出发，通过PI3K/AKT/mTOR途径探索ERBB3的mRNA和蛋白质水平差异基因特征。ERBB3在宫颈癌组织（尤其是HPV阳性和腺癌相关组织）中的高表达促进了PI3K/AKT/mTOR途径的激活。MMP9表达增加改变了肿瘤微环境中的巨噬细胞浸润，并影响宫颈癌患者的预后。总之，本研究在宫颈癌中鉴定出14个与上皮-间质转化相关的基因和30个参与PI3K/AKT/mTOR途径的基因，它们可能为未来的治疗提供新线索。MMP家族可能是与肿瘤细胞和免疫细胞相关的一个显著因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5546/9995796/0ac12a309b81/etm-25-04-11845-g14.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5546/9995796/fcff5d2e3aaf/etm-25-04-11845-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5546/9995796/0be36fdfb3ff/etm-25-04-11845-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5546/9995796/a8cc9ee5e4fa/etm-25-04-11845-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5546/9995796/874b2caf36ec/etm-25-04-11845-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5546/9995796/50e55b0debea/etm-25-04-11845-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5546/9995796/6b225e40de55/etm-25-04-11845-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5546/9995796/fba34d3fc4d7/etm-25-04-11845-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5546/9995796/639ba2c43ea6/etm-25-04-11845-g07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5546/9995796/8f6fb27803f4/etm-25-04-11845-g08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5546/9995796/06e34e1d6dc6/etm-25-04-11845-g09.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5546/9995796/cf6edcad866f/etm-25-04-11845-g10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5546/9995796/534df1bbd7d9/etm-25-04-11845-g11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5546/9995796/b24819e8504f/etm-25-04-11845-g12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5546/9995796/14f484700ddc/etm-25-04-11845-g13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5546/9995796/0ac12a309b81/etm-25-04-11845-g14.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5546/9995796/fcff5d2e3aaf/etm-25-04-11845-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5546/9995796/0be36fdfb3ff/etm-25-04-11845-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5546/9995796/a8cc9ee5e4fa/etm-25-04-11845-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5546/9995796/874b2caf36ec/etm-25-04-11845-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5546/9995796/50e55b0debea/etm-25-04-11845-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5546/9995796/6b225e40de55/etm-25-04-11845-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5546/9995796/fba34d3fc4d7/etm-25-04-11845-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5546/9995796/639ba2c43ea6/etm-25-04-11845-g07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5546/9995796/8f6fb27803f4/etm-25-04-11845-g08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5546/9995796/06e34e1d6dc6/etm-25-04-11845-g09.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5546/9995796/cf6edcad866f/etm-25-04-11845-g10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5546/9995796/534df1bbd7d9/etm-25-04-11845-g11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5546/9995796/b24819e8504f/etm-25-04-11845-g12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5546/9995796/14f484700ddc/etm-25-04-11845-g13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5546/9995796/0ac12a309b81/etm-25-04-11845-g14.jpg

相似文献

1
ERBB3 mediates the PI3K/AKT/mTOR pathway to alter the epithelial‑mesenchymal transition in cervical cancer and predict immunity filtration outcome.ERBB3介导PI3K/AKT/mTOR信号通路，改变宫颈癌中的上皮-间质转化，并预测免疫浸润结果。
Exp Ther Med. 2023 Feb 15;25(4):146. doi: 10.3892/etm.2023.11845. eCollection 2023 Apr.
2
Effects of miR-202-5p silencing PIK3CA gene expression on proliferation, invasion, and epithelial-mesenchymal transition of cervical cancer SiHa cells through inhibiting PI3K/Akt/mTOR signaling pathway activation.沉默 miR-202-5p 对 PIK3CA 基因表达的影响通过抑制 PI3K/Akt/mTOR 信号通路的激活对宫颈癌 SiHa 细胞的增殖、侵袭和上皮间质转化的作用。
Mol Cell Biochem. 2021 Nov;476(11):4031-4044. doi: 10.1007/s11010-021-04211-4. Epub 2021 Jul 9.
3
TEAD4 functions as a prognostic biomarker and triggers EMT via PI3K/AKT pathway in bladder cancer.TEAD4 在膀胱癌中作为预后生物标志物，通过 PI3K/AKT 通路触发 EMT。
J Exp Clin Cancer Res. 2022 May 17;41(1):175. doi: 10.1186/s13046-022-02377-3.
4
LINC00861 inhibits the progression of cervical cancer cells by functioning as a ceRNA for miR‑513b‑5p and regulating the PTEN/AKT/mTOR signaling pathway.LINC00861 通过作为 miR-513b-5p 的 ceRNA 并调节 PTEN/AKT/mTOR 信号通路来抑制宫颈癌细胞的进展。
Mol Med Rep. 2021 Jan;23(1). doi: 10.3892/mmr.2020.11662. Epub 2020 Nov 12.
5
Immune Pathway and Gene Database (IMPAGT) Revealed the Immune Dysregulation Dynamics and Overactivation of the PI3K/Akt Pathway in Tumor Buddings of Cervical Cancer.免疫通路与基因数据库（IMPAGT）揭示了宫颈癌肿瘤芽中PI3K/Akt通路的免疫失调动态及过度激活。
Curr Issues Mol Biol. 2022 Oct 23;44(11):5139-5152. doi: 10.3390/cimb44110350.
6
KIFC3 Promotes Proliferation, Migration, and Invasion in Colorectal Cancer PI3K/AKT/mTOR Signaling Pathway.驱动蛋白家族成员C3（KIFC3）通过PI3K/AKT/mTOR信号通路促进结直肠癌的增殖、迁移和侵袭。
Front Genet. 2022 Jun 22;13:848926. doi: 10.3389/fgene.2022.848926. eCollection 2022.
7
MicroRNA-99b suppresses human cervical cancer cell activity by inhibiting the PI3K/AKT/mTOR signaling pathway.微小 RNA-99b 通过抑制 PI3K/AKT/mTOR 信号通路抑制人宫颈癌细胞活性。
J Cell Physiol. 2019 Jun;234(6):9577-9591. doi: 10.1002/jcp.27645. Epub 2018 Nov 27.
8
ARHGAP9 inhibits colorectal cancer cell proliferation, invasion and EMT via targeting PI3K/AKT/mTOR signaling pathway.ARHGAP9 通过靶向 PI3K/AKT/mTOR 信号通路抑制结直肠癌细胞增殖、侵袭和 EMT。
Tissue Cell. 2022 Aug;77:101817. doi: 10.1016/j.tice.2022.101817. Epub 2022 May 7.
9
CEP55 promotes epithelial-mesenchymal transition in renal cell carcinoma through PI3K/AKT/mTOR pathway.CEP55 通过 PI3K/AKT/mTOR 通路促进肾细胞癌中的上皮-间充质转化。
Clin Transl Oncol. 2019 Jul;21(7):939-949. doi: 10.1007/s12094-018-02012-8. Epub 2019 Jan 3.
10
LncRNA LINC01305 silencing inhibits cell epithelial-mesenchymal transition in cervical cancer by inhibiting TNXB-mediated PI3K/Akt signalling pathway.LncRNA LINC01305 沉默通过抑制 TNXB 介导的 PI3K/Akt 信号通路抑制宫颈癌中的细胞上皮-间充质转化。
J Cell Mol Med. 2019 Apr;23(4):2656-2666. doi: 10.1111/jcmm.14161. Epub 2019 Jan 29.

引用本文的文献

1
Computational investigation of stigmasterol as a potential therapeutic agent for cervical cancer: insights from density functional theory (DFT) and molecular docking studies.豆甾醇作为宫颈癌潜在治疗剂的计算研究：来自密度泛函理论（DFT）和分子对接研究的见解
In Silico Pharmacol. 2025 May 24;13(2):77. doi: 10.1007/s40203-025-00361-1. eCollection 2025.
2
Expression of variant isoforms of the tyrosine kinase SYK differentially regulates cervical cancer progression through PI3K/AKT pathway.酪氨酸激酶 SYK 的变异异构体表达通过 PI3K/AKT 通路差异调节宫颈癌的进展。
Sci Rep. 2024 Nov 23;14(1):29080. doi: 10.1038/s41598-024-80579-9.
3

本文引用的文献

1
Constitutive Occurrence of E:N-cadherin Heterodimers in Adherens Junctions of Hepatocytes and Derived Tumors.E:N-钙黏蛋白异二聚体在肝细胞及其衍生肿瘤的黏着连接中的组成性出现。
Cells. 2022 Aug 12;11(16):2507. doi: 10.3390/cells11162507.
2
ggtranscript: an R package for the visualization and interpretation of transcript isoforms using ggplot2.ggtranscript：一个使用 ggplot2 可视化和解释转录本异构体的 R 包。
Bioinformatics. 2022 Aug 2;38(15):3844-3846. doi: 10.1093/bioinformatics/btac409.
3
ERBB3 methylation and immune infiltration in tumor microenvironment of cervical cancer.
Baicalin attenuates PD-1/PD-L1 axis-induced immunosuppression in piglets challenged with Glaesserella parasuis by inhibiting the PI3K/Akt/mTOR and RAS/MEK/ERK signalling pathways.
黄芩苷通过抑制 PI3K/Akt/mTOR 和 RAS/MEK/ERK 信号通路减轻猪多杀性巴氏杆菌攻毒仔猪 PD-1/PD-L1 轴诱导的免疫抑制。
Vet Res. 2024 Jul 29;55(1):95. doi: 10.1186/s13567-024-01355-1.
4
KLF5 inhibits the migration and invasion in cervical cancer cell lines by regulating SNAI1.KLF5 通过调节 SNAI1 抑制宫颈癌细胞系的迁移和侵袭。
Cancer Biomark. 2024;39(3):231-243. doi: 10.3233/CBM-230175.
5
Cervical Cancer Stages, Human Papillomavirus Integration, and Malignant Genetic Mutations: Integrative Analysis of Datasets from Four Different Cohorts.宫颈癌分期、人乳头瘤病毒整合与恶性基因突变：来自四个不同队列数据集的综合分析
Cancers (Basel). 2023 Nov 26;15(23):5595. doi: 10.3390/cancers15235595.
宫颈癌肿瘤微环境中 ERBB3 的甲基化和免疫浸润。
Sci Rep. 2022 May 17;12(1):8112. doi: 10.1038/s41598-022-11415-1.
4
Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives.肿瘤微环境中癌症相关成纤维细胞与免疫细胞的串扰：新发现与未来展望。
Mol Cancer. 2021 Oct 11;20(1):131. doi: 10.1186/s12943-021-01428-1.
5
Pattern recognition receptors in health and diseases.模式识别受体在健康与疾病中的作用
Signal Transduct Target Ther. 2021 Aug 4;6(1):291. doi: 10.1038/s41392-021-00687-0.
6
Web-Based Survival Analysis Tool Tailored for Medical Research (KMplot): Development and Implementation.专为医学研究量身定制的基于网络的生存分析工具（KMplot）：开发与应用
J Med Internet Res. 2021 Jul 26;23(7):e27633. doi: 10.2196/27633.
7
The Immune Microenvironment in Human Papilloma Virus-Induced Cervical Lesions-Evidence for Estrogen as an Immunomodulator.人乳头瘤病毒诱导的宫颈病变中的免疫微环境——雌激素作为免疫调节剂的证据。
Front Cell Infect Microbiol. 2021 Apr 30;11:649815. doi: 10.3389/fcimb.2021.649815. eCollection 2021.
8
Identification of EMT signaling cross-talk and gene regulatory networks by single-cell RNA sequencing.通过单细胞 RNA 测序鉴定 EMT 信号串扰和基因调控网络。
Proc Natl Acad Sci U S A. 2021 May 11;118(19). doi: 10.1073/pnas.2102050118.
9
Tumor Immune Microenvironment during Epithelial-Mesenchymal Transition.上皮-间质转化过程中的肿瘤免疫微环境。
Clin Cancer Res. 2021 Sep 1;27(17):4669-4679. doi: 10.1158/1078-0432.CCR-20-4459. Epub 2021 Apr 7.
10
The role of CD47-SIRPα immune checkpoint in tumor immune evasion and innate immunotherapy.CD47-SIRPα 免疫检查点在肿瘤免疫逃逸和固有免疫治疗中的作用。
Life Sci. 2021 May 15;273:119150. doi: 10.1016/j.lfs.2021.119150. Epub 2021 Mar 1.