ANO1 通过重编程胆固醇代谢和肿瘤微环境促进癌症转移。
ANO1 Reprograms Cholesterol Metabolism and the Tumor Microenvironment to Promote Cancer Metastasis.
机构信息
Key Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, State Key Laboratory of Respiratory Disease, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Department of Thoracic Surgery, Shanghai Chest Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
出版信息
Cancer Res. 2023 Jun 2;83(11):1851-1865. doi: 10.1158/0008-5472.CAN-22-3490.
Metastatic cancer cells upregulate ANO1 to activate cell-intrinsic and -extrinsic mechanisms that alter cholesterol metabolism and stimulate fibroblasts, which can be targeted with ANO1 inhibitors to inhibit metastatic growth. See related commentary by Singh and Mehla, p. 1759.
转移性癌细胞上调 ANO1 以激活改变胆固醇代谢并刺激成纤维细胞的细胞内和细胞外机制，ANO1 抑制剂可靶向这些机制来抑制转移性生长。见 Singh 和 Mehla 的相关评论，第 1759 页。
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