College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
Cancer Immunol Immunother. 2023 Jul;72(7):2319-2330. doi: 10.1007/s00262-023-03414-6. Epub 2023 Mar 13.
Immunotherapy has greatly changed the status of cancer treatment, and many patients do not respond or develop acquired resistance. The related research is blocked by lacking of comprehensive resources for researchers to discovery and analysis signatures, then further exploring the mechanisms. Here, we first offered a benchmarking dataset of experimentally supported signatures of cancer immunotherapy by manually curated from published literature works and provided an overview. We then developed CiTSA ( http://bio-bigdata.hrbmu.edu.cn/CiTSA/ ) which stores 878 entries of experimentally supported associations between 412 signatures such as genes, cells, and immunotherapy across 30 cancer types. CiTSA also provides flexible online tools to identify and visualize molecular/cell feature and interaction, to perform function, correlation, and survival analysis, and to execute cell clustering, cluster activity, and cell-cell communication analysis based on single cell and bulk datasets of cancer immunotherapy. In summary, we provided an overview of experimentally supported cancer immunotherapy signatures and developed CiTSA which is a comprehensive and high-quality resource and is helpful for understanding the mechanism of cancer immunity and immunotherapy, developing novel therapeutic targets and promoting precision immunotherapy for cancer.
免疫疗法极大地改变了癌症治疗的现状，但许多患者对治疗没有反应或产生获得性耐药性。由于缺乏全面的资源，相关研究受到阻碍，研究者无法发现和分析特征，进而进一步探索其机制。在这里，我们首先从已发表的文献中手动整理了一个经过实验验证的癌症免疫治疗特征基准数据集，并提供了一个概述。然后，我们开发了 CiTSA（http://bio-bigdata.hrbmu.edu.cn/CiTSA/），它存储了 30 种癌症类型中 412 个特征（如基因、细胞和免疫治疗）之间 878 个经过实验验证的关联条目。CiTSA 还提供了灵活的在线工具，用于识别和可视化分子/细胞特征和相互作用，执行功能、相关性和生存分析，以及基于癌症免疫治疗的单细胞和批量数据集执行细胞聚类、聚类活性和细胞间通讯分析。总之，我们提供了经过实验验证的癌症免疫治疗特征概述，并开发了 CiTSA，这是一个全面且高质量的资源，有助于理解癌症免疫和免疫治疗的机制，开发新的治疗靶点，并促进癌症的精准免疫治疗。
