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New Frontiers in Psoriatic Disease Research, Part I: Genetics, Environmental Triggers, Immunology, Pathophysiology, and Precision Medicine.银屑病研究的新前沿,第一部分:遗传学、环境诱因、免疫学、病理生理学和精准医学。
J Invest Dermatol. 2021 Sep;141(9):2112-2122.e3. doi: 10.1016/j.jid.2021.02.764. Epub 2021 Jul 22.
2
New Frontiers in Psoriatic Disease Research, Part II: Comorbidities and Targeted Therapies.银屑病研究的新前沿,第二部分:合并症和靶向治疗。
J Invest Dermatol. 2021 Oct;141(10):2328-2337. doi: 10.1016/j.jid.2021.02.743. Epub 2021 Apr 19.
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Comparative Efficacy and Relative Ranking of Biologics and Oral Therapies for Moderate-to-Severe Plaque Psoriasis: A Network Meta-analysis.生物制剂与口服疗法治疗中重度斑块状银屑病的疗效比较及相对排名:一项网状Meta分析
Dermatol Ther (Heidelb). 2021 Jun;11(3):885-905. doi: 10.1007/s13555-021-00511-1. Epub 2021 Mar 31.
4
Diagnostic Delay in Psoriatic Arthritis: A Population-based Study.银屑病关节炎的诊断延误:一项基于人群的研究。
J Rheumatol. 2021 Sep;48(9):1410-1416. doi: 10.3899/jrheum.201199. Epub 2021 Feb 15.
5
Aiming for Cure and Preventive Initiatives in Psoriatic Disease: Building Synergy at NPF, GRAPPA, and PPACMAN.致力于银屑病的治愈和预防举措:在 NPF、GRAPPA 和 PPACMAN 中建立协同作用。
Curr Rheumatol Rep. 2020 Sep 21;22(11):78. doi: 10.1007/s11926-020-00958-9.
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Association Between Psoriasis and Depression: A Traditional Review.银屑病与抑郁症之间的关联:一项传统综述。
Cureus. 2020 Aug 13;12(8):e9708. doi: 10.7759/cureus.9708.
7
Anti IL-17 in psoriasis.治疗银屑病的抗白细胞介素-17 疗法。
Expert Rev Clin Immunol. 2019 Nov;15(11):1185-1194. doi: 10.1080/1744666X.2020.1679625. Epub 2019 Oct 16.
8
Risankizumab compared with adalimumab in patients with moderate-to-severe plaque psoriasis (IMMvent): a randomised, double-blind, active-comparator-controlled phase 3 trial.利斯库珠单抗与阿达木单抗治疗中重度斑块型银屑病患者的疗效比较(IMMvent):一项随机、双盲、活性对照的 3 期临床试验。
Lancet. 2019 Aug 17;394(10198):576-586. doi: 10.1016/S0140-6736(19)30952-3. Epub 2019 Jul 4.
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Factors Influencing Sleep Difficulty and Sleep Quantity in the Citizen Pscientist Psoriatic Cohort.公民科学家银屑病队列中影响睡眠困难和睡眠质量的因素。
Dermatol Ther (Heidelb). 2019 Sep;9(3):511-523. doi: 10.1007/s13555-019-0306-1. Epub 2019 Jun 8.
10
A safety review of recent advancements in the treatment of psoriasis: analysis of clinical trial safety data.近期银屑病治疗进展的安全性回顾:临床试验安全性数据分析。
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寻常型银屑病与多种治疗失败并存:患者与皮肤科医生的视角

Living with Psoriasis Vulgaris and Multi-Treatment Failure: A Patient and Dermatologist Perspective.

作者信息

Spencer Riley K, Elhage Kareem G, Jin Joy Q, Davis Mitchell S, Hakimi Marwa, Bhutani Tina, Chang Howard, Liao Wilson

机构信息

Department of Dermatology, University of California San Francisco, Floor 04, Room N426, 2340 Sutter Street, Box 0808, San Francisco, CA, 94115, USA.

Midwestern University, Arizona College of Osteopathic Medicine, Glendale, AZ, USA.

出版信息

Dermatol Ther (Heidelb). 2023 Apr;13(4):857-866. doi: 10.1007/s13555-023-00907-1. Epub 2023 Mar 11.

DOI:10.1007/s13555-023-00907-1
PMID:36913122
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10060499/
Abstract

Psoriasis vulgaris is a systemic, chronic inflammatory disease affecting 2-3% of the population. Recent advances in the understanding of the pathophysiology of psoriatic disease have facilitated the development of novel therapeutic options with improved safety and efficacy. This article is coauthored by a patient with a lifelong history of psoriasis who experienced multiple treatment failures. He details his diagnosis and treatment experiences, as well as the physical, mental, and social ramifications of his skin condition. He then goes on to elaborate how evolutions in the treatment of psoriatic disease have impacted his life. This case is then discussed from the perspective of a dermatologist specializing in inflammatory skin disorders. We highlight the clinical features of psoriasis, its medical and psychosocial comorbidities, and the current landscape of psoriatic disease treatments.

摘要

寻常型银屑病是一种影响2%至3%人口的全身性慢性炎症性疾病。对银屑病疾病病理生理学认识的最新进展推动了具有更高安全性和疗效的新型治疗方案的开发。本文由一位患有终身银屑病病史且经历过多次治疗失败的患者共同撰写。他详细讲述了自己的诊断和治疗经历,以及皮肤状况对其身体、心理和社会方面的影响。然后,他阐述了银屑病治疗的进展如何影响了他的生活。接着,一位专门研究炎症性皮肤病的皮肤科医生从专业角度对该病例进行了讨论。我们重点介绍了银屑病的临床特征、其医学和心理社会合并症,以及银屑病疾病治疗的当前情况。