Bruze M, Fregert S, Gruvberger B, Persson K
Department of Occupational Dermatology, University Hospital, Lund, Sweden.
Acta Derm Venereol. 1987;67(4):315-20.
Preservative Kathon CG (K-CG) is a commercial preparation, consisting of the two active ingredients (a.i.), 2-methyl-4-isothiazolin-3-one (243-K-CG) and 5-chloro-2-methyl-4-isothiazolin-3-one (5243-K-CG) and also of other components. Both a.i. are known contact sensitizers in humans. In this study guinea pig maximization tests were performed with the a.i. in order to assess and compare the degrees of the sensitizing capacities. The animals were also rechallenged with the sensitizer and 4 chemically related compounds, all being preservatives or known ingredients in preservatives, in order to study the cross-reaction patterns. 5243-K-CG was demonstrated to be a strong sensitizer and 243-K-CG a weak sensitizer. With 5243-K-CG as the sensitizer, 4.5-dichloro-2-methyl-4-isothiazolin-3-one was a possible cross-reacting compound. Possible cross-reactivity was indicated between the a.i. when 243-K-CG was the sensitizer.
防腐剂凯松CG（K-CG）是一种商业制剂，由两种活性成分（a.i.），即2-甲基-4-异噻唑啉-3-酮（243-K-CG）和5-氯-2-甲基-4-异噻唑啉-3-酮（5243-K-CG）以及其他成分组成。两种活性成分在人类中均为已知的接触性致敏原。在本研究中，对活性成分进行了豚鼠最大化试验，以评估和比较致敏能力的程度。还用致敏剂和4种化学相关化合物对动物进行再激发试验，所有这些化合物均为防腐剂或防腐剂中的已知成分，以研究交叉反应模式。结果表明5243-K-CG是一种强致敏剂，243-K-CG是一种弱致敏剂。以5243-K-CG作为致敏剂时，4,5-二氯-2-甲基-4-异噻唑啉-3-酮是一种可能发生交叉反应的化合物。当以243-K-CG作为致敏剂时，两种活性成分之间显示出可能的交叉反应性。
