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Perm1 Protects the Heart From Pressure Overload-Induced Dysfunction by Promoting Oxidative Metabolism.Perm1通过促进氧化代谢保护心脏免受压力超负荷诱导的功能障碍。
Circulation. 2023 Mar 14;147(11):916-919. doi: 10.1161/CIRCULATIONAHA.122.060173. Epub 2023 Mar 13.
2
Perm1 promotes cardiomyocyte mitochondrial biogenesis and protects against hypoxia/reoxygenation-induced damage in mice.Perm1 促进心肌细胞线粒体生物发生,防止小鼠缺氧/复氧诱导的损伤。
J Biol Chem. 2021 Jul;297(1):100825. doi: 10.1016/j.jbc.2021.100825. Epub 2021 May 23.
3
Perm1 regulates cardiac energetics as a downstream target of the histone methyltransferase Smyd1.Perm1作为组蛋白甲基转移酶Smyd1的下游靶点调节心脏能量代谢。
PLoS One. 2020 Jun 23;15(6):e0234913. doi: 10.1371/journal.pone.0234913. eCollection 2020.
4
Phosphoproteomics of the developing heart identifies PERM1 - An outer mitochondrial membrane protein.心脏发育的磷酸蛋白质组学鉴定出 PERM1 - 一种外线粒体膜蛋白。
J Mol Cell Cardiol. 2021 May;154:41-59. doi: 10.1016/j.yjmcc.2021.01.010. Epub 2021 Feb 5.
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Perm1 enhances mitochondrial biogenesis, oxidative capacity, and fatigue resistance in adult skeletal muscle.Perm1增强成年骨骼肌中的线粒体生物合成、氧化能力和抗疲劳能力。
FASEB J. 2016 Feb;30(2):674-87. doi: 10.1096/fj.15-276360. Epub 2015 Oct 19.
6
PERM1 interacts with the MICOS-MIB complex to connect the mitochondria and sarcolemma via ankyrin B.PERM1 通过与 MICOS-MIB 复合物相互作用,通过锚蛋白 B 将线粒体和肌膜连接起来。
Nat Commun. 2021 Aug 12;12(1):4900. doi: 10.1038/s41467-021-25185-3.
7
Induction of heart failure by minimally invasive aortic constriction in mice: reduced peroxisome proliferator-activated receptor γ coactivator levels and mitochondrial dysfunction.经微创主动脉缩窄诱导的小鼠心力衰竭:过氧化物酶体增殖物激活受体 γ 共激活因子水平降低和线粒体功能障碍。
J Thorac Cardiovasc Surg. 2011 Feb;141(2):492-500, 500.e1. doi: 10.1016/j.jtcvs.2010.03.029. Epub 2010 May 5.
8
Perm1 regulates CaMKII activation and shapes skeletal muscle responses to endurance exercise training.Perm1 调节 CaMKII 的激活,并塑造骨骼肌对耐力运动训练的反应。
Mol Metab. 2019 May;23:88-97. doi: 10.1016/j.molmet.2019.02.009. Epub 2019 Feb 27.
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P66Shc Deletion Ameliorates Oxidative Stress and Cardiac Dysfunction in Pressure Overload-Induced Heart Failure.P66Shc 缺失可减轻压力超负荷诱导的心力衰竭中的氧化应激和心功能障碍。
J Card Fail. 2020 Mar;26(3):243-253. doi: 10.1016/j.cardfail.2019.09.003. Epub 2019 Sep 16.
10
Ablation of cardiac TIGAR preserves myocardial energetics and cardiac function in the pressure overload heart failure model.在压力超负荷心力衰竭模型中,消融心脏中的TIGAR可维持心肌能量代谢及心脏功能。
Am J Physiol Heart Circ Physiol. 2019 Jun 1;316(6):H1366-H1377. doi: 10.1152/ajpheart.00395.2018. Epub 2019 Mar 22.

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1
Injectable hydrogel with miR-222-engineered extracellular vesicles ameliorates myocardial ischemic reperfusion injury via mechanotransduction.含有经miR-222工程改造的细胞外囊泡的可注射水凝胶通过机械转导减轻心肌缺血再灌注损伤。
Cell Rep Med. 2025 Mar 18;6(3):101987. doi: 10.1016/j.xcrm.2025.101987. Epub 2025 Mar 3.
2
PERM1-An Emerging Transcriptional Regulator of Mitochondrial Biogenesis: A Systematic Review.PERM1—一种新兴的线粒体生物发生转录调控因子:系统评价。
Genes (Basel). 2024 Oct 9;15(10):1305. doi: 10.3390/genes15101305.
3
Cardiac maturation.心脏成熟
J Mol Cell Cardiol. 2024 Feb;187:38-50. doi: 10.1016/j.yjmcc.2023.12.008. Epub 2023 Dec 30.
4
Preserving mitochondria to treat hypertrophic cardiomyopathy: From rare mitochondrial DNA mutation to heart failure therapy?保存线粒体以治疗肥厚型心肌病:从罕见的线粒体 DNA 突变到心力衰竭治疗?
J Clin Invest. 2023 Jul 17;133(14):e171965. doi: 10.1172/JCI171965.

本文引用的文献

1
Correction: Perm1 promotes cardiomyocyte mitochondrial biogenesis and protects against hypoxia/reoxygenation-induced damage in mice.更正:Perm1促进心肌细胞线粒体生物合成并保护小鼠免受缺氧/复氧诱导的损伤。
J Biol Chem. 2021 Sep;297(3):101121. doi: 10.1016/j.jbc.2021.101121. Epub 2021 Aug 28.
2
PERM1 interacts with the MICOS-MIB complex to connect the mitochondria and sarcolemma via ankyrin B.PERM1 通过与 MICOS-MIB 复合物相互作用,通过锚蛋白 B 将线粒体和肌膜连接起来。
Nat Commun. 2021 Aug 12;12(1):4900. doi: 10.1038/s41467-021-25185-3.
3
Expert consensus document: Mitochondrial function as a therapeutic target in heart failure.专家共识文件:心力衰竭中作为治疗靶点的线粒体功能。
Nat Rev Cardiol. 2017 Apr;14(4):238-250. doi: 10.1038/nrcardio.2016.203. Epub 2016 Dec 22.
4
Role of the mitochondrial contact site and cristae organizing system in membrane architecture and dynamics.线粒体接触位点和嵴形成系统在膜结构和动力学中的作用。
Biochim Biophys Acta Mol Cell Res. 2017 Apr;1864(4):737-746. doi: 10.1016/j.bbamcr.2016.05.020. Epub 2016 Sep 7.
5
Isobaric labeling-based relative quantification in shotgun proteomics.鸟枪法蛋白质组学中基于等压标记的相对定量分析
J Proteome Res. 2014 Dec 5;13(12):5293-309. doi: 10.1021/pr500880b. Epub 2014 Nov 4.

Perm1 Protects the Heart From Pressure Overload-Induced Dysfunction by Promoting Oxidative Metabolism.

作者信息

Tachibana Shizuko, Yu Nam-Kyung, Li Ruixia, Fernandez-Costa Carolina, Liang Alex, Choi Janet, Jung Dayoen, Xiao Changchun, Kralli Anastasia, Yates John R, Ross Robert S, Cho Yoshitake

机构信息

Division of Cardiovascular Medicine, Department of Medicine, University of California, San Diego, La Jolla (S.T., R.L., A.L., J.C., D.J., R.S.R., Y.C.).

Departments of Molecular Medicine and Neurobiology (N.-K.Y., C.F.-C., J.R.Y.), The Scripps Research Institute, La Jolla, CA.

出版信息

Circulation. 2023 Mar 14;147(11):916-919. doi: 10.1161/CIRCULATIONAHA.122.060173. Epub 2023 Mar 13.

DOI:10.1161/CIRCULATIONAHA.122.060173
PMID:36913499
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10018424/
Abstract
摘要