2018 年尼日利亚 15 岁以下儿童中非恶性疟原虫感染和 IgG 血清阳性率。
Non-falciparum malaria infection and IgG seroprevalence among children under 15 years in Nigeria, 2018.
机构信息
Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, GA, 30029, USA.
BeVera Solutions, Atlanta, GA, 30341, USA.
出版信息
Nat Commun. 2023 Mar 13;14(1):1360. doi: 10.1038/s41467-023-37010-0.
Plasmodium falciparum (Pf) is the dominant malaria parasite in Nigeria though P. vivax (Pv), P. ovale (Po), and P. malariae (Pm) are also endemic. Blood samples (n = 31,234) were collected from children aged 0-14 years during a 2018 nationwide HIV survey and assayed for Plasmodium antigenemia, Plasmodium DNA, and IgG against Plasmodium MSP1-19 antigens. Of all children, 6.6% were estimated to have Pm infection and 1.4% Po infection with no Pv infections detected. The highest household wealth quintile was strongly protective against infection with Pm (aOR: 0.11, 95% CI: 0.05-0.22) or Po (aOR= 0.01, 0.00-0.10). Overall Pm seroprevalence was 34.2% (95% CI: 33.3-35.2) with lower estimates for Po (12.1%, 11.6-12.5) and Pv (6.3%, 6.0-6.7). Pm seropositivity was detected throughout the country with several local government areas showing >50% seroprevalence. Serological and DNA indicators show widespread exposure of Nigerian children to Pm with lower rates to Po and Pv.
恶性疟原虫（Pf）是尼日利亚的主要疟原虫，但也存在间日疟原虫（Pv）、卵形疟原虫（Po）和三日疟原虫（Pm）。2018 年，在全国范围内进行的艾滋病毒调查中，采集了 0-14 岁儿童的血液样本（n=31234），并检测疟原虫抗原血症、疟原虫 DNA 和针对疟原虫 MSP1-19 抗原的 IgG。所有儿童中，估计有 6.6%感染了 Pm，1.4%感染了 Po，未检测到 Pv 感染。最高的家庭财富五分位数对 Pm（优势比：0.11，95%置信区间：0.05-0.22）或 Po（优势比=0.01，0.00-0.10）感染有很强的保护作用。总体而言，Pm 血清阳性率为 34.2%（95%置信区间：33.3-35.2），Po 为 12.1%（11.6-12.5），Pv 为 6.3%（6.0-6.7）。Pm 血清阳性在全国各地均有发现，一些地方政府区域的血清阳性率超过 50%。血清学和 DNA 指标显示，尼日利亚儿童普遍接触 Pm，而接触 Po 和 Pv 的比例较低。
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