狼疮性肾炎患者外周血炎症因子水平及其临床价值的研究
Study of peripheral blood inflammatory factor levels and their clinical value in patients with lupus nephritis.
作者信息
Ye Feng, Guo Feng, Huang Yanni, Wang Shanzhi
机构信息
Department of Rheumatology and Immunology, The First Affiliated Hospital of Hainan Medical University Haikou, Hainan, China.
School of Tropical Medicine and Laboratory Medicine, Hainan Medical University Haikou, Hainan, China.
出版信息
Am J Transl Res. 2023 Feb 15;15(2):1446-1451. eCollection 2023.
OBJECTIVE
To explore the effect of traditional Chinese and western medicine on the levels of inflammatory cytokines in the peripheral blood of patients with lupus nephritis (LN).
METHODS
A total of 80 patients with LN admitted to the hospital from August 2016 to August 2017 were retrospectively analyzed. They were equally separated into an experimental group and a control group by the different types of medications. The control group was treated with western medicine, and the experimental group was treated with the combination of traditional Chinese and western medicines. The therapeutic effects were compared.
RESULTS
The levels of IL-6, IL-18 and TNF-α in the experimental group after treatment were (5.47±1.66) pg/ml, (31.66±3.87) pg/ml, and (9.28±3.06) pg/ml, respectively, which were significantly lower than (13.71±3.86) pg/ml, (68.47±4.26) pg/ml, and (22.17±6.54) pg/ml before treatment. The difference was statistically significant (t1 = 12.403, t2 = 40.450, t3 = 11.291, all P<0.001). In the control group after treatment, the levels of IL-6, IL-18 and TNF-α were (12.68±1.32) pg/ml, (68.22±3.42) pg/ml, and (19.78±5.57) pg/ml, respectively. The difference in control and experimental groups was statistically significant (t1 = 21.501, t2 = 44.771, t3 = 10.449, P<0.001). The total effective rate was 95.00% (38/40) in the experimental group and 80.00% (32/40) in control group, (X = 4.114, P<0.001). There SLEDAI scores of the experimental group were much lower than control after 8 and 12 weeks of treatment (t1 = 8.186, t2 = 20.776, P<0.001). Moreover, the liver and kidney Yin deficiency symptoms in both groups were significantly improved after treatment (P<0.01).
CONCLUSION
The combined treatment of traditional Chinese and western medicine can successfully prevent the secretion of serum IL-6, IL-18 and TNF-α, control the development of disease, boost the therapeutic outcome, and alleviate the immune injury of the body.
目的
探讨中西医结合对狼疮性肾炎（LN）患者外周血炎症细胞因子水平的影响。
方法
回顾性分析2016年8月至2017年8月收治的80例LN患者。根据用药类型将其平均分为实验组和对照组。对照组采用西药治疗，实验组采用中西医结合治疗。比较两组治疗效果。
结果
实验组治疗后IL-6、IL-18和TNF-α水平分别为（5.47±1.66）pg/ml、（31.66±3.87）pg/ml和（9.28±3.06）pg/ml，显著低于治疗前的（13.71±3.86）pg/ml、（68.47±4.26）pg/ml和（22.17±6.54）pg/ml。差异有统计学意义（t1 = 12.403，t2 = 40.450，t3 = 11.291，均P<0.001）。对照组治疗后IL-6、IL-18和TNF-α水平分别为（12.68±1.32）pg/ml、（68.22±3.42）pg/ml和（19.78±5.57）pg/ml。对照组与实验组差异有统计学意义（t1 = 21.501，t2 = 44.771，t3 = 10.449，P<0.001）。实验组总有效率为95.00%（38/40），对照组为80.00%（32/40），（X = 4.114，P<0.001）。治疗8周和12周后，实验组SLEDAI评分远低于对照组（t1 = 8.186，t2 = 20.776，P<0.001）。此外，两组肝肾阴虚症状治疗后均明显改善（P<0.01）。
结论
中西医结合治疗可成功抑制血清IL-6、IL-18和TNF-α的分泌，控制病情发展，提高治疗效果，减轻机体免疫损伤。
Zotero 插件