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Strategies for generating mouse model resources of human disease.

作者信息

Pan Jirong, Zhang Ling, Huang Zhibing, Zhao Dalu, Li He, Fu Yanan, Wang Meng, Chen Borui, Iraqi Fuad A, Morahan Grant, Qin Chuan

机构信息

National Human Diseases Animal Model Resource Center, NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Key Laboratory for Animal Models of Emerging and Reemerging Infectious Diseases, Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, Institute of Laboratory Animal Sciences, CAMS & PUMC, National Center of Technology Innovation for Animal Model, Changping National Laboratory (CPNL), Beijing 102206, China.

Department of Clinical Microbiology and Immunology, Sackler Faculty of Medicine, Tel-Aviv University, Ramat Aviv, Tel Aviv 69978, Israel.

出版信息

Protein Cell. 2023 Dec 1;14(12):866-870. doi: 10.1093/procel/pwad011.

DOI:10.1093/procel/pwad011
PMID:36916412
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10691848/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/90e9/10691848/7b6e41817f5d/pwad011_fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/90e9/10691848/10ceceff7ab6/pwad011_fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/90e9/10691848/195239ce7a93/pwad011_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/90e9/10691848/3da4e1a5e604/pwad011_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/90e9/10691848/7b6e41817f5d/pwad011_fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/90e9/10691848/10ceceff7ab6/pwad011_fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/90e9/10691848/195239ce7a93/pwad011_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/90e9/10691848/3da4e1a5e604/pwad011_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/90e9/10691848/7b6e41817f5d/pwad011_fig3.jpg

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本文引用的文献

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[Effects of Interleukin-6 Gene Knockout on β-amyloid Deposition and Cognition in 5×FAD Mouse Model of Alzheimer's Disease].[白细胞介素-6基因敲除对阿尔茨海默病5×FAD小鼠模型中β-淀粉样蛋白沉积及认知的影响]
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2022 Jun;44(3):357-365. doi: 10.3881/j.issn.1000-503X.14483.
2
The impact of genetic background on mouse models of kidney disease.遗传背景对肾脏疾病小鼠模型的影响。
Kidney Int. 2022 Jul;102(1):38-44. doi: 10.1016/j.kint.2022.03.020. Epub 2022 Apr 13.
3
Discovery and implications of polygenicity of common diseases.
常见疾病多基因遗传的发现及其意义。
Science. 2021 Sep 24;373(6562):1468-1473. doi: 10.1126/science.abi8206. Epub 2021 Sep 23.
4
Novel spontaneous myelodysplastic syndrome mouse model.新型自发性骨髓增生异常综合征小鼠模型。
Animal Model Exp Med. 2021 May 14;4(2):169-180. doi: 10.1002/ame2.12168. eCollection 2021 Jun.
5
Designing and generating a mouse model: frequently asked questions.设计和构建小鼠模型：常见问题解答。
J Biomed Res. 2021 Mar 26;35(2):76-90. doi: 10.7555/JBR.35.20200197.
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LIM homeodomain transcription factor Isl1 affects urethral epithelium differentiation and apoptosis via Shh.LIM 同源盒转录因子 Isl1 通过 Shh 影响尿道上皮细胞分化和凋亡。
Cell Death Dis. 2019 Sep 26;10(10):713. doi: 10.1038/s41419-019-1952-z.
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Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations.全基因组多基因疾病风险评分可识别出与单基因突变风险相当的个体。
Nat Genet. 2018 Sep;50(9):1219-1224. doi: 10.1038/s41588-018-0183-z. Epub 2018 Aug 13.
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Identification of new loci involved in the host susceptibility to Salmonella Typhimurium in collaborative cross mice.鉴定合作杂交小鼠中与鼠伤寒沙门氏菌宿主易感性相关的新基因座。
BMC Genomics. 2018 Apr 27;19(1):303. doi: 10.1186/s12864-018-4667-0.
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Down-Regulated Drebrin Aggravates Cognitive Impairments in a Mouse Model of Alzheimer's Disease.下调的 drebrin 加重阿尔茨海默病小鼠模型的认知障碍。
Int J Mol Sci. 2017 Apr 11;18(4):800. doi: 10.3390/ijms18040800.
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