Department of Dermatology, the First Hospital of Hebei Medical University, Shijiazhuang, China.
Department of Clinical Psychology, the First Hospital of Hebei Medical University, Shijiazhuang, China.
Skin Pharmacol Physiol. 2023;36(3):160-164. doi: 10.1159/000530140. Epub 2023 Mar 14.
Autism is a neurodevelopmental disorder. Individuals with autism can exhibit multiple neurological symptoms such as deficit in social communication, restricted interests, and repetitive behaviors. Recent study showed that murine model of autism displays an increased transepidermal water loss (TEWL) and dry skin. But whether epidermal functions are also altered in children with autism is unknown. In the present study, TEWL, stratum corneum hydration, and skin surface pH were compared between children with autism (N = 56) and normal controls (N = 48). Our results showed that children with autism exhibited lower stratum corneum hydration levels, higher TEWL, and elevated skin surface pH in comparison to normal controls (p < 0.0001 for all). These results demonstrate that children with autism exhibit epidermal dysfunction.
自闭症是一种神经发育障碍。自闭症患者可能表现出多种神经系统症状，如社交沟通缺陷、兴趣受限和重复行为。最近的研究表明，自闭症的小鼠模型表现出经皮水分丢失（TEWL）增加和皮肤干燥。但是自闭症儿童的表皮功能是否也发生改变尚不清楚。在本研究中，我们比较了自闭症儿童（N=56）和正常对照组（N=48）之间的 TEWL、角质层含水量和皮肤表面 pH 值。我们的结果表明，与正常对照组相比，自闭症儿童的角质层含水量较低，TEWL 较高，皮肤表面 pH 值升高（所有 p < 0.0001）。这些结果表明自闭症儿童存在表皮功能障碍。
