建立和应用测试方法学，以证明空气净化系统在减少室内空气中载有病毒的气溶胶方面的功能。
Establishment and application of test methodology demonstrating the functionality of air purification systems in reducing virus-loaded aerosol in indoor air.
机构信息
Department of Microbiology and Systems Biology, The Netherlands Organisation for Applied Scientific Research TNO, Leiden, the Netherlands.
Department of Microbiology and Systems Biology, The Netherlands Organisation for Applied Scientific Research TNO, Leiden, the Netherlands.
出版信息
J Hosp Infect. 2023 May;135:74-80. doi: 10.1016/j.jhin.2023.03.004. Epub 2023 Mar 12.
BACKGROUND
The global COVID-19 pandemic has resulted in a greater interest in improving the ventilation of indoor environments in order to remove aerosolized virus and thus reduce transmission. Air purification systems have been proposed as a solution to improve aerosol removal.
AIM
The aim was to determine the efficacy of air purification systems in reducing the viral load in the environmental air of a room.
METHODS
A containment room equipped with HEPA filter on air intake and exhaust was constructed. It was connected via an inlet with the BSL-2 facility. From the BSL-2, Feline Coronavirus (FCoV)-loaded aerosols were released into the containment room. After nebulization, air sampling was performed to determine the viral load in air prior to assessing the clean air delivery rate of the air purification systems. The infectivity of the captured viruses was also examined.
FINDINGS
The air purification systems realized a 97-99% reduction in viral load in air in 1 h. Captured infectious FCoV was reduced by 99.9%-99.99% by use of an ESP technology.
CONCLUSIONS
The air purification systems, using ESP technology or HEPA filter, reduce the viral load in air. The ESP purifiers inactivate captured FCoV viruses. Therefore, air purification systems can be used as an adjunctive infection control measure.
背景
全球 COVID-19 大流行导致人们更加关注改善室内环境的通风，以去除气溶胶化的病毒，从而降低传播风险。空气净化系统已被提议作为改善气溶胶去除的解决方案。
目的
旨在确定空气净化系统在降低室内环境空气中病毒载量方面的效果。
方法
建造了一个带有进气和排气高效空气过滤器的密闭室。它通过入口与 BSL-2 设施相连。从 BSL-2 中，将负载猫冠状病毒 (FCoV) 的气溶胶释放到密闭室中。喷雾后，进行空气采样以确定空气净化系统的清洁空气输送率之前的空气中的病毒载量。还检查了捕获病毒的感染力。
结果
空气净化系统在 1 小时内将空气中的病毒载量减少了 97%-99%。使用 ESP 技术，捕获的传染性 FCoV 减少了 99.9%-99.99%。
结论
使用 ESP 技术或高效空气过滤器的空气净化系统可降低空气中的病毒载量。ESP 净化器可使捕获的 FCoV 病毒失活。因此，空气净化系统可用作辅助感染控制措施。
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