Reply to: Genome-wide association studies of polygenic risk score-derived phenotypes may lead to inflated false positive rates.
作者信息
Guerreiro Rita, Bras Jose
机构信息
Department of Neurodegenerative Science, Van Andel Institute, Grand Rapids, MI, USA.
出版信息
Sci Rep. 2023 Mar 14;13(1):4264. doi: 10.1038/s41598-023-29953-7.
Abstract
摘要
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Reply to: Genome-wide association studies of polygenic risk score-derived phenotypes may lead to inflated false positive rates.回复：对多基因风险评分衍生表型的全基因组关联研究可能导致假阳性率虚高。
Sci Rep. 2023 Mar 14;13(1):4264. doi: 10.1038/s41598-023-29953-7.
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本文引用的文献
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Genome-wide association studies of polygenic risk score-derived phenotypes may lead to inflated false positive rates.对多基因风险评分衍生表型的全基因组关联研究可能会导致假阳性率虚高。
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Genome-wide association studies for Alzheimer's disease: bigger is not always better.阿尔茨海默病的全基因组关联研究：规模越大未必越好。
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Genome-wide association of polygenic risk extremes for Alzheimer's disease in the UK Biobank.英国生物库中阿尔茨海默病多基因风险极值的全基因组关联分析。
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A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease.一项针对 1126563 人的全基因组关联研究确定了阿尔茨海默病的新风险基因座。
Nat Genet. 2021 Sep;53(9):1276-1282. doi: 10.1038/s41588-021-00921-z. Epub 2021 Sep 7.
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Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk.全基因组荟萃分析确定了新的位点和功能途径，影响阿尔茨海默病的风险。
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