随机、双盲、四臂先导研究鸡精华和 II 型胶原蛋白水解物对关节、骨骼和肌肉功能的影响。
Randomized, double-blind, four-arm pilot study on the effects of chicken essence and type II collagen hydrolysate on joint, bone, and muscle functions.
机构信息
Department of Orthopedic Surgery, Chang Gung Memorial Hospital, Linkou, No. 5, Fuxing Street, Guishan District, Taoyuan City 333, Taiwan.
College of Medicine, Chang Gung University, No. 259, Wenhua 1st Road, Guishan District, Taoyuan City, 333, Taiwan.
出版信息
Nutr J. 2023 Mar 15;22(1):17. doi: 10.1186/s12937-023-00837-w.
BACKGROUND
Knee osteoarthritis (OA) is a leading cause of disability among older adults. Medical and surgical treatments are costly and associated with side effects. A natural nutraceutical, collagen hydrolysate, has received considerable attention due to its relieving effects on OA-associated symptoms. This study investigated the effects of hydrolyzed collagen type II (HC-II) and essence of chicken (BRAND'S Essence of Chicken) with added HC-II (EC-HC-II) on joint, muscle, and bone functions among older adults with OA.
METHODS
Patients (n = 160) with grade 1-3 knee OA according to the Kellgren-Lawrence classification system, joint pain for ≥ 3 months, and a Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score of > 6 were randomly assigned with equal probability to consume EC-HC-II, HC-II, glucosamine HCl, or a placebo for 24 weeks in combination with resistance training. Outcome measurements were WOMAC score, visual analogue scale (VAS) pain score, grip strength, fat-free mass (FFM), and bone mass.
RESULTS
All groups exhibited similar levels of improvement in WOMAC index scores after 24 weeks. HC-II significantly reduced VAS pain score by 0.9 ± 1.89 (p = 0.034) after 14 days. A repeated-measures analysis of variance showed that HC-II reduced pain levels more than the placebo did (mean ± standard error: - 1.3 ± 0.45, p = 0.021) after 14 days; the EC-HC-II group also had significantly higher FFM than the glucosamine HCl (p = 0.02) and placebo (p = 0.017) groups and significantly higher grip strength than the glucosamine HCl group (p = 0.002) at 24 weeks.
CONCLUSION
HC-II reduces pain, and EC-HC-II may improve FFM and muscle strength. This suggests that EC-HC-II may be a novel holistic solution for mobility by improving joint, muscle, and bone health among older adults. Large-scale studies should be conducted to validate these findings.
TRIAL REGISTRATION
This trial was retrospectively registered at ClinicalTrials.gov (NCT04483024).
背景
膝关节骨关节炎（OA）是老年人致残的主要原因。医学和手术治疗费用高昂，并伴有副作用。一种天然的营养保健品，水解胶原蛋白，因其对 OA 相关症状的缓解作用而受到广泛关注。本研究调查了水解 II 型胶原蛋白（HC-II）和添加 HC-II 的鸡汤精华（BRAND'SEssence of Chicken，EC-HC-II）对 OA 老年患者关节、肌肉和骨骼功能的影响。
方法
根据 Kellgren-Lawrence 分级系统，160 名患有 1-3 级膝关节 OA、关节疼痛≥3 个月且 Western Ontario and McMaster Universities Osteoarthritis Index（WOMAC）评分>6 的患者被随机平均分配，接受 EC-HC-II、HC-II、盐酸氨基葡萄糖或安慰剂治疗 24 周，同时进行抗阻训练。主要结局指标为 WOMAC 评分、视觉模拟评分（VAS）疼痛评分、握力、去脂体重（FFM）和骨密度。
结果
24 周后，所有组的 WOMAC 指数评分均有相似程度的改善。HC-II 在 14 天后可显著降低 0.9±1.89 的 VAS 疼痛评分（p=0.034）。重复测量方差分析显示，HC-II 降低疼痛的效果优于安慰剂（平均±标准误差：-1.3±0.45，p=0.021），14 天后；EC-HC-II 组的 FFM 也显著高于盐酸氨基葡萄糖（p=0.02）和安慰剂（p=0.017）组，握力显著高于盐酸氨基葡萄糖组（p=0.002），24 周后。
结论
HC-II 可减轻疼痛，EC-HC-II 可能改善 FFM 和肌肉力量。这表明，EC-HC-II 可能通过改善老年人的关节、肌肉和骨骼健康，为提高移动能力提供一种新的整体解决方案。应开展大规模研究来验证这些发现。
试验注册
本试验在 ClinicalTrials.gov（NCT04483024）进行了回顾性注册。
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