Poudineh Maryam, Ghotbi Tahere, Azizi Farnoush, Karami Nooshin, Zolfaghari Zahra, Gheisari Farshid, Hormozi Mohammad, Poudineh Sahar
School of Medicine, Mashhad Azad University, Mashhad, Iran.
Department of Nursing, School of Nursing and Midwifery, Shiraz University of Medical Science, Shiraz, Iran.
Galen Med J. 2022 Nov 12;11:e2337. doi: 10.31661/gmj.v11i.2337. eCollection 2022.
Neurological complications are considered the leading cause of disability and the second cause of death worldwide. Although the most common neurological disorders affecting a large population are Alzheimer's (AD) and Parkinson's diseases (PD), no definitive treatment has been propounded in the clinic. As in recent years, special attention has been paid to medicinal herbal products as one of the ways to meet the challenges of treating diseases. This review study aimed to introduce the naringin neuroprotective effects as an abundant flavonoid in grapes and citrus fruits on the most common neurological disorders, including AD and PD. For this purpose, the specified keywords were searched in PubMed, Web of Science, Scopus, Embase, and Google Scholar, and the results were entered into the study after a concise overview. The findings show naringin can confront neurological disorders through several mechanisms such as modulating stress response pathways, preventing apoptosis, oxidative stress, and neuroinflammation, excessive chelating amounts of metal ions, thereby improving cognitive impairment and memory loss induced by neurological disorders. However, further studies, particularly on human, are critical for the final confirmation of obtained findings. [GMJ.2022;11:e2337].
神经并发症被认为是全球致残的主要原因和第二大致死原因。尽管影响大量人群的最常见神经疾病是阿尔茨海默病（AD）和帕金森病（PD），但临床上尚未提出明确的治疗方法。近年来，药用草药产品作为应对疾病治疗挑战的一种方式受到了特别关注。本综述旨在介绍柚皮苷作为葡萄和柑橘类水果中丰富的黄酮类化合物，对包括AD和PD在内的最常见神经疾病的神经保护作用。为此，在PubMed、科学网、Scopus、Embase和谷歌学术中搜索了特定关键词，并在简要概述后将结果纳入研究。研究结果表明，柚皮苷可以通过多种机制对抗神经疾病，如调节应激反应途径、防止细胞凋亡、氧化应激和神经炎症、过度螯合金属离子，从而改善神经疾病引起的认知障碍和记忆丧失。然而，进一步的研究，特别是对人类的研究，对于最终证实所获结果至关重要。[《胃肠病学与肝病学杂志》.2022；11：e2337]
