Department of Paediatrics, Nelson Hospital, Nelson, New Zealand.
Department of Paediatrics, University of Otago, Christchurch, New Zealand.
Clin Microbiol Rev. 2023 Jun 21;36(2):e0012622. doi: 10.1128/cmr.00126-22. Epub 2023 Mar 15.
In 2007, the World Health Organization (WHO) launched a global health initiative for the elimination of mother-to-child transmission (MTCT) of syphilis. This condition is highly preventable through antenatal identification of syphilis infection and treatment with penicillin during pregnancy. This review summarizes the global status of MTCT of syphilis and concludes that this condition remains a significant issue worldwide. There are large variations in case rates by region, with the highest numbers of cases in the African and Eastern Mediterranean regions, where there are also the least data available. There are also pockets of high-incidence areas within the other regions. Although the general trend is of decreasing rates over time, there are concerning indications of consistently increasing congenital syphilis cases in some areas, particularly in areas which have previously had very low case numbers. A concerted effort will be required to achieve the 2007 WHO goal of worldwide elimination of MTCT of syphilis in the near future.
2007 年，世界卫生组织（WHO）发起了一项消除梅毒母婴传播全球倡议。通过在产前识别梅毒感染并在怀孕期间用青霉素治疗，这种疾病是可以高度预防的。本综述总结了梅毒母婴传播的全球状况，并得出结论认为，这种情况在全球范围内仍然是一个重大问题。不同地区的病例发生率存在很大差异，非洲和东地中海地区的病例数量最多，而这些地区的数据也最少。在其他地区也存在一些高发病率地区。尽管总体趋势是随着时间的推移发病率逐渐下降，但在一些地区，包括以前病例数量非常低的地区，仍有令人担忧的先天梅毒病例持续增加的迹象。为了在不久的将来实现 2007 年世卫组织消除梅毒母婴传播的目标，需要做出协调一致的努力。
