Recent Advances in the Syntheses of N-CF Scaffolds up to Their Valorization.

This review provides a recent overview of the different synthetic routes of the N-CF group. This scaffold can be prepared from the desulfurization of thiocabamoyl fluorides or isothiocyanates with fluoride ions. Electrophilic and radical trifluoromethylations are also a great way to generate this motif. This report also focuses on the valorization of some N-CF compounds, which leads to new unknown N-trifluoromethyl derivatives. Finally, the first metabolic stability studies will be given for certain structures.