Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, UK.
Population Health Sciences and MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
J Clin Psychiatry. 2023 Jan 25;84(2):22m14379. doi: 10.4088/jcp.22m14379.
Attention Deficit Hyperactivity Disorder (ADHD) is associated with a range of adverse outcomes in adult life. However it is unclear whether the risk pathways to adverse adult outcomes are established during childhood or whether associations are driven by concurrent ADHD symptoms that have persisted to adulthood.
We examined associations between broadly defined child-limited (remitted) and persistent ADHD (assessed using the ADHD subscale of the Strengths and Difficulties Questionnaire) with social outcomes (low emotional and instrumental support, antisocial behaviour, employment, receipt of state benefits as an indicator of socio-economic disadvantage, homelessness) at age 25 years in a UK longitudinal population sample ALPSAC (the Avon Longitudinal Study of Parents and Children, age 25 data collected between years 2017 and 2018): total N=6439.
Up to 20% of young-people with less favourable social outcomes at age 25 had persistent ADHD. Persistent ADHD was associated with an increased likelihood of being not in education, employment or training (NEET: OR=3.71, 95% CI=2.06 to 6.67, p=1x10) and receiving state benefits (OR=2.72, 95% CI=1.62 to 4.57, p=2x10) at age 25 years compared to those without ADHD. We did not find strong evidence of associations between child-limited ADHD and social outcomes (NEET OR=1.20, 95% CI=0.54 to 2.69, p=0.65; state benefits OR=1.38, 95% CI=0.76 to 2.51, p=0.29). Persistent ADHD associations with negative social outcomes were observed across family-of-origin income groups, sex and were not explained by comorbidity.
Our findings highlight the importance of continued monitoring and management of ADHD symptoms and related social as well as clinical outcomes across development into adulthood. Future research is needed to identify what factors promote positive social outcomes, including effective treatment of adult ADHD symptoms.
注意力缺陷多动障碍(ADHD)与成年后一系列不良后果有关。然而,尚不清楚导致不良成年后果的风险途径是在儿童期建立的,还是与持续到成年期的并发 ADHD 症状有关。
我们研究了在英国纵向人群样本 ALPSAC(阿冯纵向研究父母和儿童,25 岁数据收集于 2017 年至 2018 年之间)中,使用 ADHD 量表(Strengths and Difficulties Questionnaire 的 ADHD 子量表)广泛定义的儿童期有限(缓解)和持续性 ADHD 与 25 岁时的社会结果(低情感和工具性支持、反社会行为、就业、领取国家福利作为社会经济劣势的指标、无家可归)之间的关联:总样本量为 6439 名。
多达 20%的 25 岁社会结果较差的年轻人存在持续性 ADHD。持续性 ADHD 与未接受教育、就业或培训(NEET:比值比[OR]=3.71,95%置信区间[CI]为 2.06 至 6.67,p=1x10)和领取国家福利(OR=2.72,95% CI=1.62 至 4.57,p=2x10)的可能性增加有关,而与无 ADHD 的年轻人相比。我们没有发现 ADHD 与社会结果(NEET OR=1.20,95% CI=0.54 至 2.69,p=0.65;国家福利 OR=1.38,95% CI=0.76 至 2.51,p=0.29)之间存在强关联的有力证据。在原籍家庭收入群体、性别方面均观察到持续性 ADHD 与负面社会结果之间的关联,且不能用共病来解释。
我们的研究结果强调了在整个儿童期到成年期,持续监测和管理 ADHD 症状以及相关社会和临床结果的重要性。未来的研究需要确定哪些因素促进了积极的社会结果,包括有效治疗成人 ADHD 症状。