与小肠中细胞更新模式改变相关的生长刺激活性。
Growth stimulating activity associated with an altered cell renewal pattern in the small intestine.
作者信息
Grey V L, Kenscoff J M, Morin C L
机构信息
Centre de Recherche Pédiatrique, Hôpital Ste-Justine, Montreal, Quebec, Canada.
出版信息
Gut. 1987;28 Suppl(Suppl):15-7. doi: 10.1136/gut.28.suppl.15.
A growth stimulating activity has been recently identified in the rat proximal intestine during the transient stages of adaptation after small bowel resection. This study shows that the growth stimulating activity is associated with all the cells of the crypt-villus axis. At the same time the thymidine kinase activity is detectable in all the cells implying a more extensive proliferative zone during the transient stages of adaptation. The presence of the growth stimulating activity along with the more extensive proliferative zone suggests that the activity modulates the proliferation capacity of intestinal epithelial cells.
最近在大鼠小肠切除术后适应的短暂阶段，已在大鼠近端肠道中鉴定出一种生长刺激活性。这项研究表明，生长刺激活性与隐窝 - 绒毛轴的所有细胞相关。同时，在所有细胞中均可检测到胸苷激酶活性，这意味着在适应的短暂阶段存在更广泛的增殖区。生长刺激活性的存在以及更广泛的增殖区表明，该活性调节肠道上皮细胞的增殖能力。
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