Fernández-Quirós Judith, Lacasa-Cazcarra Marcos, Alegre-Martín Jose, Sanmartín-Sentañes Ramón, Almirall Miriam, Launois-Obregón Patricia, Castro-Marrero Jesús, Rodríguez-Urrutia Amanda, Navarro-Sanchis Jose A, Ramos-Quiroga J Antoni
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Unit, Division of Rheumatology, Vall d'Hebron Hospital Research Institute Universitat Autònoma de Barcelona, Barcelona, Spain.
Department of Mental Health, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
Front Psychol. 2023 Feb 27;14:1127193. doi: 10.3389/fpsyg.2023.1127193. eCollection 2023.
The main objective is to delimit the cognitive dysfunction associated with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) in adult patients by applying the Continuous Performance Test (CPT3). Additionally, provide empirical evidence on the usefulness of this computerized neuropsychological test to assess ME/CFS.
The final sample ( = 225; 158 Patients/67 Healthy controls) were recruited in a Central Sensitization Syndromes (CSS) specialized unit in a tertiary hospital. All participants were administered this neuropsychological test.
There were significant differences between ME/CFS and healthy controls in all the main measures of CPT3. Mainly, patients had a worse indicator of inattentiveness, sustained attention, vigilance, impulsivity, slow reaction time, and more atypical T-scores, which is associated with a likelihood of having a disorder characterized by attention deficits, such as Attention Deficit Hyperactivity Disorder (ADHD). In addition, relevant correlations were obtained between the CPT3 variables in the patient's group. The most discriminative indicators of ME/CFS patients were Variability and Hit Reaction Time, both measures of response speed.
The CPT3 is a helpful tool to discriminate neurocognitive impairments from attention and response speed in ME/CFS patients, and it could be used as a marker of ME/CFS severity for diagnosing or monitoring this disease.
主要目的是通过应用连续性能测试（CPT3）来界定成年肌痛性脑脊髓炎/慢性疲劳综合征（ME/CFS）患者的认知功能障碍。此外，提供关于这种计算机化神经心理测试评估ME/CFS有效性的实证证据。
最终样本（n = 225；158名患者/67名健康对照）在一家三级医院的中枢敏化综合征（CSS）专科单位招募。所有参与者都接受了这项神经心理测试。
在CPT3的所有主要指标上，ME/CFS患者与健康对照之间存在显著差异。主要表现为，患者在注意力不集中、持续注意力、警觉性、冲动性、反应时间缓慢等方面指标较差，且T分数更不典型，这与患有以注意力缺陷为特征的疾病（如注意力缺陷多动障碍（ADHD））的可能性相关。此外，在患者组中CPT3变量之间获得了相关关系。ME/CFS患者最具区分性的指标是变异性和命中反应时间，这两个指标均为反应速度的测量指标。
CPT3是区分ME/CFS患者注意力和反应速度方面神经认知障碍的有用工具，可作为诊断或监测该疾病的ME/CFS严重程度标志物。
