LaNCE-Neuropharm Group, Neuroscience Dep., University of the Basque Country (UPV-EHU), Leioa, Bizkaia, Spain.
Experimental Psychology Laboratory, CONICET, Dep. Pathology, UNC, Mendoza, Argentina.
J Transl Med. 2021 Dec 4;19(1):494. doi: 10.1186/s12967-021-03153-1.
The maintained attention is the cause of great functional limitations in CFS/ME, a disease that mainly affects women in the central period of life. Cognitive function is explored using the Montreal Cognitive Assessment, the maintained attention using the Toulouse-Piéron test with which the Global Index of Attention and Perception (GIAP) is obtained, the fatigue using the visual analog scale and the perception of effort using the modified Borg scale. The final sample were 84 patients (66 women/18 men) who met diagnostic criteria (Fukuda-1994, Carruthers-2011) and 22 healthy controls (14 women/8 men). Most of patients maintain normal cognitive function, showing low or very low attention score in the 70% of patients with a marked cognitive fatigue compared to the control group (p < 0.05). There were no significant differences between genders in GIAP or fatigue for CFS/ME; however, sick women perceive cognitive effort higher than men. Deficits in sustained attention and the perception of fatigue, so effort after performing the proposed test are a sensitive and reliable indicator that allows us to substantiate a clinical suspicion and refer patients for further studies in order to confirm or rule out CFS/ME.
维持注意力是 CFS/ME（慢性疲劳综合征/肌痛性脑脊髓炎）的主要功能障碍的原因，这种疾病主要影响处于生命中期的女性。认知功能使用蒙特利尔认知评估进行探索，维持注意力使用图卢兹-皮埃隆测试进行，该测试获得注意力和感知全局指数（GIAP），疲劳使用视觉模拟量表，努力感知使用改良的 Borg 量表。最终样本包括符合诊断标准（Fukuda-1994、Carruthers-2011）的 84 名患者（66 名女性/18 名男性）和 22 名健康对照组（14 名女性/8 名男性）。大多数患者保持正常的认知功能，与对照组相比，70%的患者注意力得分较低或非常低，表现出明显的认知疲劳（p<0.05）。CFS/ME 患者在 GIAP 或疲劳方面，性别之间没有显著差异；然而，患病女性比男性感知到更高的认知努力。维持注意力和疲劳感知的缺陷，以及在进行所提议的测试后的努力，是一种敏感且可靠的指标，可以证实临床怀疑，并将患者转介进行进一步研究，以确认或排除 CFS/ME。
