Ware Megan, O'Connor Patrick, Bub Kristen, Backus Deborah, McCully Kevin
St Jude Children's Research Hospital, Memphis, TN, USA (MW).
Department of Kinesiology (MW, POC, KMC), College of Education, University of Georgia, Athens, GA, USA.
Int J MS Care. 2023 Mar-Apr;25(2):75-81. doi: 10.7224/1537-2073.2022-007. Epub 2022 Sep 13.
Fatigue is a particularly debilitating symptom for people with multiple sclerosis (MS). Although personality traits and MS have been studied, interoception and emotional susceptibility and their links to fatigue have not yet been explored.
Study participants provided demographic information and completed standardized patient-reported outcomes of walking function, physical activity, subjective fatigue, interoceptive awareness, and emotional susceptibility. A subset of participants participated in semistructured interviews discussing fatigue, body sensations, emotions, and their effects on exercise. Quantitative data were analyzed using multiple regression. Qualitative data were analyzed using thematic analysis.
Mean ± SD Fatigue Severity Scale scores (5.0 ± 1.3) indicated that fatigue was a problematic symptom. Mean ± SD Multidimensional Assessment of Interoceptive Awareness, Version 2 (2.8 ± 0.6) and Emotional Susceptibility Scale (3.0 ± 1.0) scores indicated lower levels of interoceptive awareness and emotional susceptibility. Quantitative data indicated no relationship between fatigue and interoceptive awareness (β = -0.20; = .88) and emotional susceptibility (β = 0.03; = .83), and neither were these related to physical activity (β = -0.07; = .64). Qualitative themes indicated strong fatigue experiences involving the whole body and individual limbs, anger and frustration, and effects on physical activity.
Physically active people with MS report strong sensations of fatigue closely linked to frustration and helplessness. There was agreement between qualitative and quantitative assessments of fatigue but dissonance regarding interoceptive awareness and physical activity. The practice of clinicians, particularly those involved with facilitating or planning physical activity for persons with MS, would benefit from these findings about fatigue.
疲劳是多发性硬化症（MS）患者特别使人衰弱的症状。虽然已经对人格特质与MS进行了研究，但尚未探讨内感受、情绪易感性及其与疲劳的联系。
研究参与者提供了人口统计学信息，并完成了关于步行功能、身体活动、主观疲劳、内感受意识和情绪易感性的标准化患者报告结局。一部分参与者参加了半结构化访谈，讨论疲劳、身体感觉、情绪及其对运动的影响。定量数据采用多元回归分析。定性数据采用主题分析。
疲劳严重程度量表平均±标准差得分（5.0±1.3）表明疲劳是一个有问题的症状。内感受意识多维评估第2版平均±标准差得分（2.8±0.6）和情绪易感性量表得分（3.0±1.0）表明内感受意识和情绪易感性水平较低。定量数据表明疲劳与内感受意识（β=-0.20；P=.88）和情绪易感性（β=0.03；P=.83）之间无关联，且这些均与身体活动无关（β=-0.07；P=.64）。定性主题表明强烈的疲劳体验涉及全身和个别肢体、愤怒和沮丧以及对身体活动的影响。
积极运动的MS患者报告强烈的疲劳感，这与沮丧和无助密切相关。疲劳的定性和定量评估之间存在一致性，但在内感受意识和身体活动方面存在不一致。临床医生的实践，尤其是那些参与为MS患者促进或规划身体活动的医生，将从这些关于疲劳的发现中受益。
