Cammarata Marco, Piazza Francesco, Rivas Germán, Schirò Giorgio, Temussi Piero Andrea, Pastore Annalisa
Experiment Division, European Synchrotron Radiation Facility, 71 Ave des Martyrs, Grenoble, France.
Department of Physics & Astronomy, University of Florence and INFN Sezione di Firenze, Sesto Fiorentino, Italy.
Front Mol Biosci. 2023 Feb 27;10:1153996. doi: 10.3389/fmolb.2023.1153996. eCollection 2023.
Taking into account the presence of the crowded environment of a macromolecule has been an important goal of biology over the past 20 years. Molecular crowding affects the motions, stability and the kinetic behaviour of proteins. New powerful approaches have recently been developed to study molecular crowding, some of which make use of the synchrotron radiation light. The meeting "New Frontiers in Molecular Crowding" was organized in July 2022at the European Synchrotron Radiation facility of Grenoble to discuss the new frontiers of molecular crowding. The workshop brought together researchers from different disciplines to highlight the new developments of the field, including areas where new techniques allow the scientists to gain unprecedently expected information. A key conclusion of the meeting was the need to build an international and interdisciplinary research community through enhanced communication, resource-sharing, and educational initiatives that could let the molecular crowding field flourish further.
在过去20年里，考虑到生物大分子所处的拥挤环境一直是生物学的一个重要目标。分子拥挤会影响蛋白质的运动、稳定性和动力学行为。最近已经开发出了一些强大的新方法来研究分子拥挤，其中一些方法利用了同步辐射光。“分子拥挤的新前沿”会议于2022年7月在格勒诺布尔的欧洲同步辐射设施举行，旨在讨论分子拥挤的新前沿。该研讨会汇聚了来自不同学科的研究人员，以突出该领域的新进展，包括新技术使科学家能够获得前所未有的预期信息的领域。会议的一个关键结论是，需要通过加强交流、资源共享和教育举措来建立一个国际跨学科研究社区，从而使分子拥挤领域能够进一步蓬勃发展。
