Oluwasina Olugbenga Oludayo, Idris Suleiman Oladokun, Ogidi Clement Olusola, Igbe Festus O
Department of Chemistry, The Federal University of Technology Akure, PMB 704, Akure, Ondo State, Nigeria.
Department of Food Science and Technology, School of Agriculture, Food and Natural Resources, Olusegun Agagu University of Science and Technology, PMB 353, Okitipupa, Nigeria.
Heliyon. 2023 Feb 28;9(3):e13892. doi: 10.1016/j.heliyon.2023.e13892. eCollection 2023 Mar.
To investigate the possibility of producing dental antimicrobial toothpaste from L skin chaff, seed, and pod extracts.
Ethanolic extracts of the three plant materials were obtained. These were subjected to phytochemical and GC-MS analyses. The different extract combinations were used for the production of various toothpaste. The toothpaste's physical, organoleptic, and antimicrobial properties were determined.
From the phytochemical analysis, has the highest phenolic (1.20 mgGAE/g), saponin (14.80%), tannin (0.11 mg/g) and DPPH (82.80%), has the highest flavonoid (0.33 mg RE/g), and alkaloid (20.50 mg/g) while, has the highest oxalate (77.50 mg/g). The GC-MS revealed significant chemical components of as 1-heptatriacotanol, germacra-1(10),4,11(13)-trien-12-oic acid, 6-alpha-hydroxy-,gamma-lactone, (E,E)-, 11H-Indeno [1,2b] quinoxaline, 2-methyl- while have butyl benzoate, benzoic acid, hexyl ester, hexadecanoic acid, methyl ester and have the following 15-hydroxypentadecanoic acid, -9-hexadecenal, and 11,13-dimethyl-12-tetradecen-1-ol acetate. All the produced toothpaste has a brown colour and a pleasant smell, with pH from 7.30 to 8.10 and foamability from 19.23% of stand-alone toothpaste to 44.44% of -based. Amongst the produced toothpaste -based toothpaste has the best antimicrobial activities against the tested bacteria (, ) and fungi ( and ). The stand-alone toothpaste has the lowest minimum inhibitory concentration of 1.25 mg/mL against bacteria and fungi.
The study provides information on the production of human health-friendly dental antimicrobial toothpaste from plant materials.
研究利用荔枝果皮、种子和豆荚提取物生产具有抗菌作用的牙膏的可能性。
获取这三种植物材料的乙醇提取物。对其进行植物化学分析和气相色谱 - 质谱联用（GC - MS）分析。将不同的提取物组合用于生产各种牙膏。测定牙膏的物理、感官和抗菌性能。
植物化学分析表明，荔枝果皮的酚类物质含量最高（1.20 mgGAE/g）、皂苷含量最高（14.80%）、单宁含量最高（0.11 mg/g）以及二苯基苦味酰基自由基清除率（DPPH）最高（82.80%）；荔枝种子的黄酮类物质含量最高（0.33 mg RE/g）以及生物碱含量最高（20.50 mg/g）；而荔枝豆荚的草酸盐含量最高（77.50 mg/g）。GC - MS分析显示，荔枝果皮的主要化学成分有1 - 二十七烷醇、大根香叶 - 1(10),4,11(13) - 三烯 - 12 - 酸、6 - α - 羟基 - γ - 内酯、(E,E) - 、11H - 茚并[1,2b]喹喔啉、2 - 甲基 - ；荔枝种子含有苯甲酸丁酯、苯甲酸己酯、十六烷酸甲酯；荔枝豆荚含有15 - 羟基十五烷酸、 - 9 - 十六碳烯醛以及11,13 - 二甲基 - 12 - 十四碳烯 - 1 - 醇乙酸酯。所有生产出的牙膏均呈棕色且气味宜人，pH值在7.30至8.10之间，起泡性从单独牙膏的19.23%到基于荔枝果皮提取物牙膏的44.44%。在所生产的牙膏中，基于荔枝果皮提取物的牙膏对受试细菌（ 、 ）和真菌（ 和 ）具有最佳的抗菌活性。单独牙膏对细菌和真菌的最低抑菌浓度最低，为1.25 mg/mL。
该研究为利用植物材料生产对人类健康有益的抗菌牙膏提供了信息。
