Production of herbal toothpaste: Physical, organoleptic, phyto-compound, and antimicrobial properties.

OBJECTIVE

To investigate the possibility of producing dental antimicrobial toothpaste from L skin chaff, seed, and pod extracts.

METHODS

Ethanolic extracts of the three plant materials were obtained. These were subjected to phytochemical and GC-MS analyses. The different extract combinations were used for the production of various toothpaste. The toothpaste's physical, organoleptic, and antimicrobial properties were determined.

RESULTS

From the phytochemical analysis, has the highest phenolic (1.20 mgGAE/g), saponin (14.80%), tannin (0.11 mg/g) and DPPH (82.80%), has the highest flavonoid (0.33 mg RE/g), and alkaloid (20.50 mg/g) while, has the highest oxalate (77.50 mg/g). The GC-MS revealed significant chemical components of as 1-heptatriacotanol, germacra-1(10),4,11(13)-trien-12-oic acid, 6-alpha-hydroxy-,gamma-lactone, (E,E)-, 11H-Indeno [1,2b] quinoxaline, 2-methyl- while have butyl benzoate, benzoic acid, hexyl ester, hexadecanoic acid, methyl ester and have the following 15-hydroxypentadecanoic acid, -9-hexadecenal, and 11,13-dimethyl-12-tetradecen-1-ol acetate. All the produced toothpaste has a brown colour and a pleasant smell, with pH from 7.30 to 8.10 and foamability from 19.23% of stand-alone toothpaste to 44.44% of -based. Amongst the produced toothpaste -based toothpaste has the best antimicrobial activities against the tested bacteria (, ) and fungi ( and ). The stand-alone toothpaste has the lowest minimum inhibitory concentration of 1.25 mg/mL against bacteria and fungi.

CLINICAL SIGNIFICANCE

The study provides information on the production of human health-friendly dental antimicrobial toothpaste from plant materials.