Nikfallah Azarmidokht, Mohammadi Ali, Ahmadakhondi Mohammadsadegh, Ansari Mehdi
Department of Pharmaceutics, Faculty of Pharmacy, Damghan Branch, Islamic Azad University, Damghan, Iran.
Pharmaceutical Quality Assurance Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran.
Heliyon. 2023 Oct 12;9(10):e20924. doi: 10.1016/j.heliyon.2023.e20924. eCollection 2023 Oct.
The key characteristics of mesoporous hydroxyapatite, such as high porosity and expansive surface area, along with its biocompatibility with dental tissues and potential as a delivery vehicle for active ingredients, have recently garnered significant research focus. In the present study, mesoporous hydroxyapatite was synthesized using a precipitation technique and was subsequently characterized via X-ray diffraction, Fourier transform infrared, dynamic light scattering, field emission scanning electron microscopy and N adsorption-desorption isotherms. The results revealed that the synthesized mesopore particles exhibited significant adsorption potential, and were thereby considered a carrier of thymol, an effective antibacterial on oral pathogens. Specifically, mesoporous hydroxyapatite's surface area and pore volume were approximately 2.66-fold and 1.95-fold higher than hydroxyapatite's. A statistically significant divergence in the release profiles of thymol from thymol-loaded mesoporous hydroxyapatite and thymol-loaded hydroxyapatite was noted, as indicated by the similarity factor (f < 50). Evaluation of organoleptic parameters (taste, odor, smoothness, appearance) showed that thymol-loaded mesoporous hydroxyapatite toothpaste had superior organoleptic attributes compared to thymol-loaded hydroxyapatite toothpaste. However, both formulations were acceptable regarding pH and stability and were desirable regarding abrasiveness with no significant difference compared to the standard formulation (p > 0.05). Overall, the findings demonstrate the suitability of mesoporous hydroxyapatite as an abrasive material for developing hydroxyapatite-based toothpaste formulations.
介孔羟基磷灰石的关键特性，如高孔隙率和大表面积，以及其与牙齿组织的生物相容性和作为活性成分载体的潜力，最近受到了大量研究关注。在本研究中，采用沉淀技术合成了介孔羟基磷灰石，并随后通过X射线衍射、傅里叶变换红外光谱、动态光散射、场发射扫描电子显微镜和N吸附-脱附等温线对其进行了表征。结果表明，合成的介孔颗粒具有显著的吸附潜力，因此被认为是百里酚（一种对口腔病原体有效的抗菌剂）的载体。具体而言，介孔羟基磷灰石的表面积和孔体积分别比羟基磷灰石高约2.66倍和1.95倍。如相似因子所示（f < 50），载百里酚介孔羟基磷灰石和载百里酚羟基磷灰石中百里酚的释放曲线存在统计学上的显著差异。感官参数（味道、气味、光滑度、外观）评估表明，载百里酚介孔羟基磷灰石牙膏相比载百里酚羟基磷灰石牙膏具有更优的感官特性。然而，两种配方在pH值和稳定性方面均可接受，在磨蚀性方面也令人满意，与标准配方相比无显著差异（p > 0.05）。总体而言，研究结果表明介孔羟基磷灰石作为一种磨料材料适用于开发基于羟基磷灰石的牙膏配方。
