Department of Medical Microbiology and Immunology, Faculty of Medicine (For Girls), Al-Azhar University, Cairo 11754, Nasr City, Egypt.
Department of Pediatrics, Ain Shams University, Cairo 11391, Abbaseia, Egypt.
World J Gastroenterol. 2023 Feb 21;29(7):1123-1130. doi: 10.3748/wjg.v29.i7.1123.
The risk of liver injury in patients with coronavirus disease 2019 (COVID-19) infection is quite evident. Furthermore, liver function test abnormalities are still detected in COVID-19 patients despite the development of antivirals and the availability of several types of vaccines. This editorial describes liver involvement during COVID-19 infection in patients with or without preexisting liver injury, such as chronic liver disease, to elucidate COVID-19-induced liver function abnormalities and their severity, pathophysiology, clinical manifestations, and clinical and laboratory outcomes. We also discuss the effect of vaccination against COVID-19 to better understand host factors, such as age, gender, and race, on the incidence and severity of liver dysfunction at initial presentation and during the illness. Finally, we summarize the results of relevant meta-analyses published to date and highlight the importance of adequate liver function monitoring in the current climate of the overwhelming COVID-19 pandemic.
新型冠状病毒病 2019（COVID-19）感染患者的肝损伤风险相当明显。此外，尽管开发了抗病毒药物和多种类型的疫苗，但 COVID-19 患者仍存在肝功能试验异常。本社论描述了有或没有预先存在的肝损伤（如慢性肝病）的 COVID-19 感染患者的肝脏受累情况，以阐明 COVID-19 引起的肝功能异常及其严重程度、病理生理学、临床表现以及临床和实验室结果。我们还讨论了 COVID-19 疫苗接种的效果，以更好地了解宿主因素，如年龄、性别和种族，对初始表现和疾病过程中肝功能障碍发生率和严重程度的影响。最后，我们总结了迄今为止发表的相关荟萃分析的结果，并强调了在 COVID-19 大流行的严峻形势下，充分监测肝功能的重要性。
