打开你的骨吸收细胞窗孔，吸收我吧！
Open Thy Lattice Osteoclast, Resorb me!
机构信息
Laboratory Genes and Disease, Department of Laboratory Medicine, Medical University of Vienna , Vienna, Austria.
出版信息
J Cell Biol. 2023 Apr 3;222(4). doi: 10.1083/jcb.202302033. Epub 2023 Mar 16.
Abstract
Osteoclasts degrade bone using Cathepsin K and two metalloproteinases: MMP9 and MMP14. In addition to cleaving collagen, Zhu et al. (2023. J. Cell Biol.https://doi.org/10.1083/jcb.202206121) discover that MMP9 and MMP14 also proteolyze galectin-3 on the cell surface. This process drives a galectin-3/LRP1 signaling axis that supports the hard tissue-resorbing function of osteoclasts.
摘要
破骨细胞利用组织蛋白酶 K 和两种金属蛋白酶 MMP9 和 MMP14 降解骨。除了切割胶原外，Zhu 等人（2023. J. Cell Biol. https://doi.org/10.1083/jcb.202206121）还发现 MMP9 和 MMP14 还可在细胞表面水解半乳糖凝集素-3。这一过程驱动半乳糖凝集素-3/LRP1 信号轴，支持破骨细胞的硬组织吸收功能。
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本文引用的文献
1
Osteoclast biology in the single-cell era.单细胞时代的破骨细胞生物学
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2
Galectin-3- and phospho-caveolin-1-dependent outside-in integrin signaling mediates the EGF motogenic response in mammary cancer cells.半乳糖凝集素-3 和磷酸化质膜窖蛋白-1 依赖性整合素外向信号转导介导表皮生长因子促迁移反应在乳腺癌细胞中。
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Rho GTPases in osteoclasts: orchestrators of podosome arrangement.破骨细胞中的Rho GTP酶：足体排列的协调者
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Molecular regulation of osteoclast activity.破骨细胞活性的分子调控
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Galectin-3 is a downstream regulator of matrix metalloproteinase-9 function during endochondral bone formation.半乳糖凝集素-3是软骨内骨形成过程中基质金属蛋白酶-9功能的下游调节因子。
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