Laboratory Genes and Disease, Department of Laboratory Medicine, Medical University of Vienna , Vienna, Austria.
J Cell Biol. 2023 Apr 3;222(4). doi: 10.1083/jcb.202302033. Epub 2023 Mar 16.
Osteoclasts degrade bone using Cathepsin K and two metalloproteinases: MMP9 and MMP14. In addition to cleaving collagen, Zhu et al. (2023. J. Cell Biol.https://doi.org/10.1083/jcb.202206121) discover that MMP9 and MMP14 also proteolyze galectin-3 on the cell surface. This process drives a galectin-3/LRP1 signaling axis that supports the hard tissue-resorbing function of osteoclasts.
破骨细胞利用组织蛋白酶 K 和两种金属蛋白酶 MMP9 和 MMP14 降解骨。除了切割胶原外，Zhu 等人（2023. J. Cell Biol. https://doi.org/10.1083/jcb.202206121）还发现 MMP9 和 MMP14 还可在细胞表面水解半乳糖凝集素-3。这一过程驱动半乳糖凝集素-3/LRP1 信号轴，支持破骨细胞的硬组织吸收功能。
