Johnson C A, Armstrong P J, Hauptman J G
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing 48824-1314.
J Am Vet Med Assoc. 1987 Dec 1;191(11):1478-83.
Congenital portosystemic shunts (CPSS) were diagnosed in 46 dogs. The historic, physical, and laboratory findings were tabulated. Half of the affected males were cryptorchid. Urolithiasis was detected in 20% of the dogs. The biochemical tests with the best sensitivity for the diagnosis of CPSS were sulfobromophthalein retention, fasting serum ammonia concentration, and serum alkaline phosphatase activity. The survival time and quality of life were assessed by physical and biochemical reevaluation of the dogs and by means of a questionnaire that was completed by the owners. Five dogs were treated medically. Thirty-three dogs were treated surgically. Dogs that had complete surgical occlusion of the CPSS became normal, and quality of life was excellent. Dogs that had partial occlusion of the CPSS improved, and some became clinically normal. Dogs that did not have surgical correction of the CPSS had continuation of signs, but several survived for years.
46只犬被诊断为先天性门体分流（CPSS）。将病史、体格检查和实验室检查结果制成表格。半数患病雄性犬为隐睾。20%的犬检测出尿石症。对CPSS诊断敏感性最高的生化检查是酚四溴酞钠潴留、空腹血清氨浓度和血清碱性磷酸酶活性。通过对犬进行体格和生化复查以及主人填写的问卷来评估生存时间和生活质量。5只犬接受药物治疗。33只犬接受手术治疗。CPSS完全手术闭塞的犬恢复正常，生活质量极佳。CPSS部分闭塞的犬病情改善，一些犬临床症状消失。未进行CPSS手术矫正的犬症状持续存在，但有几只存活了数年。
