宫内 SARS-CoV-2 感染母亲的足月婴儿在 16 至 18 个月时的发育筛查。
Developmental screening of full-term infants at 16 to 18 months of age after in-utero exposure to maternal SARS-CoV-2 infection.
机构信息
Division of Neonatology, Department of Pediatrics, New York University Grossman School of Medicine, New York, NY, USA.
Department of Psychology, Pace University, New York, NY, USA.
出版信息
J Perinatol. 2023 May;43(5):659-663. doi: 10.1038/s41372-023-01642-3. Epub 2023 Mar 17.
OBJECTIVE
To screen for neurodevelopmental delays in a cohort of full-term infants born to mothers with SARS-CoV-2.
STUDY DESIGN
This was a prospective, descriptive cohort study of full-term infants born to mothers with SARS-CoV-2 during pregnancy. Subjects underwent neurodevelopmental screening using the Ages and Stages Questionnaires-Third Edition (ASQ-3) at 16 to 18 months age.
RESULTS
Of 51 subjects, twelve (24%) were below cutoff, and twenty-seven (53%) were either below or close to the cutoff in at least one developmental domain. Communication (29%), fine motor (31%), and problem-solving (24%) were the most affected domains. There were no differences in outcomes between infants born to asymptomatic and mildly symptomatic mothers.
CONCLUSION
We observed increased risk of neurodevelopmental delays during screening of infants born at full-term to mothers with SARS-CoV-2 at 16 to 18 months age. These results highlight the urgent need for follow-up studies of infants born to mothers with SARS-CoV-2.
目的
对 SARS-CoV-2 感染孕妇所娩足月婴儿进行神经发育迟缓筛查。
研究设计
这是一项前瞻性描述性队列研究，纳入 SARS-CoV-2 感染孕妇所娩足月婴儿。在婴儿 16 至 18 月龄时使用年龄与阶段问卷第三版（ASQ-3）进行神经发育筛查。
结果
51 名婴儿中，12 名（24%）低于临界值，27 名（53%）在至少一个发育领域低于或接近临界值。受影响最严重的领域是沟通（29%）、精细运动（31%）和解决问题（24%）。无症状和轻度症状母亲所娩婴儿的结局无差异。
结论
我们观察到，在 16 至 18 月龄时对 SARS-CoV-2 感染孕妇所娩足月婴儿进行筛查时，神经发育迟缓的风险增加。这些结果突出表明，迫切需要对 SARS-CoV-2 感染孕妇所娩婴儿进行随访研究。
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