Yan Zishuo, Tran Huy, Ma Dezun, Xie Jingwei
Department of Surgery-Transplant and Mary & Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Department of Mechanical and Materials Engineering, University of Nebraska Lincoln, Lincoln, NE 68588, USA.
Mater Interfaces. 2024 Dec;1(1):13-34. doi: 10.53941/mi.2024.100004. Epub 2024 Nov 21.
Emerging piezoelectric metamaterials hold immense promise for biomedical applications by merging the intrinsic electrical properties of piezoelectricity with the precise architecture of metamaterials. This review provides a comprehensive overview of various piezoelectric materials- such as molecular crystals, ceramics, and polymers-known for their exceptional piezoelectric performance and biocompatibility. We explore the advanced engineering approaches, including molecular design, supramolecular packing, and 3D assembly, which enable the customization of piezoelectric properties for targeted biomedical applications. Particular attention is given to the pivotal role of metamaterial structuring in the development of 0D spheres, 1D fibers and tubes, 2D films, and 3D scaffolds. Key biomedical applications, including tissue engineering, drug delivery, wound healing, and biosensing, are discussed through illustrative examples. Finally, the article addresses critical challenges and future directions, aiming to drive further innovations in piezoelectric biomaterials for next-generation healthcare technologies.
新兴的压电超材料通过将压电性的固有电学特性与超材料的精确结构相结合，在生物医学应用方面具有巨大潜力。本综述全面概述了各种以其卓越的压电性能和生物相容性而闻名的压电材料，如分子晶体、陶瓷和聚合物。我们探讨了先进的工程方法，包括分子设计、超分子堆积和三维组装，这些方法能够针对特定的生物医学应用定制压电性能。特别关注超材料结构在零维球体、一维纤维和管、二维薄膜及三维支架开发中的关键作用。通过示例讨论了关键的生物医学应用，包括组织工程、药物递送、伤口愈合和生物传感。最后，本文阐述了关键挑战和未来方向，旨在推动用于下一代医疗技术的压电生物材料的进一步创新。
