Affiliated Hospital of Weifang Medical University, School of Clinical Medicine, Weifang Medical University, Weifang, China.
Front Endocrinol (Lausanne). 2023 Mar 2;14:1108394. doi: 10.3389/fendo.2023.1108394. eCollection 2023.
Targeted retinal photocoagulation (TRP) is an emerging laser technology for retinal targeted therapy. TRP can specifically act on unperfused retinal capillaries and retinal intermediate ischemic areas, reduce damage to tissue perfusion areas and panretinal photocoagulation (PRP) complications or adverse events. In this regard, this review discusses the treatment options, efficacy, and latest progress of TRP for diabetic retinopathy (DR) based on randomized controlled trial (RCT), meta-analysis, case review, and other existing studies.
In-depth research was conducted on articles about the proposal and development of TRP, its simple application in DR, and combined therapy. In order to review the new progress, application methods, effects, and prospects of TRP in the treatment of DR, the articles related to TRP in the databases of PubMed and Web Of Science since this century were comprehensively analyzed.
TRP is effective in treating DR and may become a substitute for PRP in the future. In addition, the treatment regimen of TRP combined with intravitreal injection of anti-vascular endothelial growth factor (anti-VEGF) drugs can also be used as a new therapeutic approach to expand the treatment regimen for the treatment of DR, and this combination therapy also has effects on other retinal vascular diseases.
With the advancement of technology, TRP has been continuously applied in clinical practice, and its potential benefits have opened up broad prospects for the treatment of DR. The combination therapy of TRP and anti-VEGF is expected to become a new option for patients with DR an retinal diseases.
靶向视网膜光凝术（TRP）是一种新兴的视网膜靶向治疗激光技术。TRP 可以特异性作用于无灌注的视网膜毛细血管和视网膜中间缺血区，减少对组织灌注区和全视网膜光凝（PRP）的损伤以及并发症或不良事件。在这方面，本综述讨论了基于随机对照试验（RCT）、荟萃分析、病例回顾和其他现有研究的 TRP 治疗糖尿病视网膜病变（DR）的治疗选择、疗效和最新进展。
深入研究了关于 TRP 提案和发展、其在 DR 中的简单应用以及联合治疗的文章。为了综述 TRP 在 DR 治疗中的新进展、应用方法、效果和前景，全面分析了本世纪以来在 PubMed 和 Web Of Science 数据库中与 TRP 相关的文章。
TRP 治疗 DR 有效，未来可能替代 PRP。此外，TRP 联合玻璃体内注射抗血管内皮生长因子（anti-VEGF）药物的治疗方案也可作为治疗 DR 的新治疗方法，这种联合治疗对其他视网膜血管疾病也有效果。
随着技术的进步，TRP 不断在临床实践中得到应用，其潜在的益处为 DR 的治疗开辟了广阔的前景。TRP 和抗 VEGF 的联合治疗有望成为 DR 和视网膜疾病患者的新选择。
