State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; School of Chemical and Material Engineering, Jiangnan University, Wuxi, Jiangsu 214122, China.
School of Chemical and Material Engineering, Jiangnan University, Wuxi, Jiangsu 214122, China.
Int J Biol Macromol. 2023 Feb 1;227:17-26. doi: 10.1016/j.ijbiomac.2022.12.049. Epub 2022 Dec 9.
Assemblies of as called "chitosan hydrogel-liposome" are expected for overcoming the burst effect in drug release from chitosan (CS) hydrogels. Herein, a hydrogel delivery system made of chitosan incorporated fatty acid vesicles was constructed for protective sustained release of curcumin (Cur). The curcumin was encapsulated in the prepared oligo-conjugated linoleic acid vesicles (OCLAVs), and then the drug-embedded vesicles were constructed to Cur-OCLAVs-CS hydrogels with CS solution. The fabricated Cur-OCLAVs-CS hydrogel was fluidic at room temperature and could be rapidly gelled at 37 °C. Morphology study proves that the OCLAVs stayed as nano-vesicles in the gel. The Cur-OCLAVs-CS hydrogels effectively declined the burst effect with enhanced antioxidant activity. The Cur (400 μM)-OCLAVs-CS gel presented a cumulative release rate of 51.23 % of curcumin in 96 h, comparing to 93.37 % of that from the Cur-CS gel. Moreover, the corporation of OCLAVs and CS made the gel exhibited strong synergistic effect on the antioxidant activity, with an enhancement of up to 148.1 % on the ferric reducing power. Therefore, the hydrogel carrier made of incorporated fatty acid vesicles-chitosan can be served as an injectable or 3D printable drug delivery system, which may provide a hint to overcome the burst effect that existed in chitosan and other polysaccharide-based gels.
所谓的“壳聚糖水凝胶-脂质体”组装体有望克服壳聚糖 (CS) 水凝胶中药物释放的突释效应。本文构建了一种由壳聚糖结合脂肪酸囊泡组成的水凝胶递药系统，用于姜黄素 (Cur) 的保护性持续释放。姜黄素被包裹在制备的寡共轭亚油酸囊泡 (OCLAVs) 中，然后将载药囊泡构建到具有 CS 溶液的 Cur-OCLAVs-CS 水凝胶中。所制备的 Cur-OCLAVs-CS 水凝胶在室温下呈流动性，在 37°C 时可迅速凝胶化。形态学研究证明，OCLAVs 在凝胶中保持为纳米囊泡。Cur-OCLAVs-CS 水凝胶有效地降低了突释效应，同时增强了抗氧化活性。与 Cur-CS 凝胶相比，Cur（400 μM）-OCLAVs-CS 凝胶在 96 小时内的累积释放率为姜黄素的 51.23%。此外，OCLAVs 和 CS 的结合使凝胶对抗氧化活性表现出很强的协同作用，铁还原力提高了高达 148.1%。因此，由结合脂肪酸囊泡-壳聚糖制成的水凝胶载体可以用作可注射或 3D 可打印的药物递送系统，这可能为克服壳聚糖和其他多糖基凝胶中存在的突释效应提供一个提示。
