从Decne.根际土壤的sp. HFF16中分离得到的具有抗糖尿病活性的异戊烯基化吲哚类萜
Prenylated indole-terpenoids with antidiabetic activities from sp. HFF16 from the rhizosphere soil of Decne.
作者信息
Liu Xijin, Kong Fandong, Xiao Na, Li Xiaoyu, Zhang Mingyu, Lv Fujin, Liu Xiaolin, Kong Xiangchuan, Bi Jing, Lu Xinyi, Kong Daqing, Hao Gangping, Zhou Liman, Pan Guojun
机构信息
College of Life Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an, Shandong, China.
Key Laboratory of Chemistry and Engineering of Forest Products, State Ethnic Affairs Commission, Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, Guangxi Collaborative Innovation Center for Chemistry and Engineering of Forest Products, School of Chemistry and Chemical Engineering, Guangxi Minzu University, Nanning, China.
出版信息
Front Microbiol. 2023 Mar 2;14:1099103. doi: 10.3389/fmicb.2023.1099103. eCollection 2023.
Finding novel and effective suppression of hepatic glucagon response antidiabetic compounds is urgently required for the development of new drugs against diabetes. Fungi are well known for their ability to produce new bioactive secondary metabolites. In this study, four new prenylated indole-terpenoids (), named encindolenes I-L, as well as a known analogue (), were isolated from the fungus sp. HFF16from the rhizosphere soil of Decne. The structures of the compounds were elucidated by spectroscopic data and ECD analysis. In the antidiabetic activity assay, compounds could inhibit glucagon-induced hepatic glucose output with EC values of 67.23, 102.1, 49.46, 25.20, and 35.96 μM, respectively, and decrease the intracellular cAMP contents in primary hepatocytes.
开发新型抗糖尿病药物迫切需要找到能有效抑制肝脏胰高血糖素反应的抗糖尿病化合物。真菌以其产生新的生物活性次级代谢产物的能力而闻名。在本研究中，从Decne根际土壤中的真菌sp. HFF16中分离出四种新的异戊烯基化吲哚 - 萜类化合物（命名为encindolenes I - L）以及一种已知类似物。通过光谱数据和ECD分析阐明了这些化合物的结构。在抗糖尿病活性测定中，这些化合物能够抑制胰高血糖素诱导的肝脏葡萄糖输出，其EC值分别为67.23、102.1、49.46、25.20和35.96 μM，并降低原代肝细胞内的cAMP含量。
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