从与Decne.根际土壤相关的sp. HFF16中分离得到的具有抗炎活性的吲哚-萜类化合物
Indole-Terpenoids With Anti-inflammatory Activities From sp. HFF16 Associated With the Rhizosphere Soil of Decne.
作者信息
Pan Guojun, Zhao Yanfen, Ren Shuang, Liu Fengyang, Xu Qicai, Pan Weibin, Yang Tongtao, Yang Mingtian, Zhang Xinru, Peng Chuanyue, Hao Gangping, Kong Fandong, Zhou Liman, Xiao Na
机构信息
College of Life Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an, China.
Key Laboratory of Chemistry and Engineering of Forest Products, State Ethnic Affairs Commission, Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, Guangxi Collaborative Innovation Center for Chemistry and Engineering of Forest Products, School of Chemistry and Chemical Engineering, Guangxi University for Nationalities, Nanning, China.
出版信息
Front Microbiol. 2021 Jul 9;12:710364. doi: 10.3389/fmicb.2021.710364. eCollection 2021.
Four new indole-terpenoids named encindolene A, 18--methyl-encindolene A, encindolene B, and encindolene C, as well as three known analogs , were isolated from the fungus sp. HFF16 from the rhizosphere soil of Decne. The structures of compounds including absolute configurations were elucidated by spectroscopic data and electronic circular dichroism (ECD) analysis. Anti-inflammatory activity evaluation revealed that compounds inhibit the production of nitric oxide with IC values of 79.4, 49.7, 81.3, 40.2, 86.7, 90.1, and 54.4 μM, respectively, and decrease the levels of tumor necrosis factor-α, interleukin-6 contents in lipopolysaccharide-induced RAW264.7 macrophages.
从Decne根际土壤中的真菌sp. HFF16中分离出四种新的吲哚 - 萜类化合物，分别命名为恩辛多林A、18 - 甲基 - 恩辛多林A、恩辛多林B和恩辛多林C，以及三种已知类似物。通过光谱数据和电子圆二色性（ECD）分析阐明了包括绝对构型在内的化合物结构。抗炎活性评估表明，这些化合物抑制一氧化氮的产生，IC值分别为79.4、49.7、81.3、40.2、86.7、90.1和54.4 μM，并降低脂多糖诱导的RAW264.7巨噬细胞中肿瘤坏死因子-α、白细胞介素-6的含量。
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