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队列效应和时期效应作为痴呆症趋势下降和认知老化的解释

Cohort and Period Effects as Explanations for Declining Dementia Trends and Cognitive Aging.

作者信息

Clouston Sean A P, Muñiz Terrera Graciela, Rodgers Joseph Lee, O'Keefe Patrick, Mann Frank, Lewis Nathan A, Wänström Linda, Kaye Jeffrey, Hofer Scott M

机构信息

Program in Public Health and Department of Family, Population, and Preventive Medicine, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY, USA.

Biostatistics and Epidemiology, Center for Dementia Prevention, University of Edinburgh, Edinburgh, UK.

出版信息

Popul Dev Rev. 2021 Sep;47(3):611-637. doi: 10.1111/padr.12409. Epub 2021 Jul 13.

Abstract

Studies have reported that the age-adjusted incidence of cognitive impairment and dementia may have decreased over the past two decades. Aging is the predominant risk factor for Alzheimer's disease and related dementias and for neurocognitive decline. However, aging cannot explain changes in overall age-adjusted incidence of dementia. The objective of this position paper was to describe the potential for cohort and period effects in cognitive decline and incidence of dementia. Cohort effects have long been reported in demographic literature, but starting in the early 1980s, researchers began reporting cohort trends in cognitive function. At the same time, period effects have emerged in economic factors and stressors in early and midlife that may result in reduced cognitive dysfunction. Recognizing that aging individuals today were once children and adolescents, and that research has clearly noted that childhood cognitive performance is a primary determinant of old-age cognitive performance, this is the first study that proposes the need to connect known cohort effects in childhood cognition with differences in late-life functioning.

摘要

研究报告称,在过去二十年中,经年龄调整后的认知障碍和痴呆症发病率可能有所下降。衰老是阿尔茨海默病及相关痴呆症以及神经认知衰退的主要风险因素。然而,衰老无法解释痴呆症总体年龄调整发病率的变化。本立场文件的目的是描述队列效应和时期效应在认知衰退和痴呆症发病率方面的可能性。队列效应在人口统计学文献中早有报道,但从20世纪80年代初开始,研究人员开始报告认知功能的队列趋势。与此同时,在经济因素以及早年和中年的压力源方面出现了时期效应,这可能会导致认知功能障碍减少。认识到如今的老年人曾经是儿童和青少年,并且研究已明确指出儿童时期的认知表现是老年认知表现的主要决定因素,这是第一项提出有必要将儿童认知中已知的队列效应与晚年功能差异联系起来的研究。

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