Lee T M, Greenberger P A, Oh S, Patterson R, Roberts M, Liotta J L
Department of Medicine, Northwestern University Medical School, Chicago, IL 60611.
J Allergy Clin Immunol. 1987 Dec;80(6):816-20. doi: 10.1016/s0091-6749(87)80271-3.
A patient with an illness consistent with allergic bronchopulmonary candidiasis is described. The patient had asthma, atelectatic pulmonary infiltrates on three occasions, immediate cutaneous reactivity as low as 10(-7) (wt/vol) to Candida albicans extract, and precipitating antibody to this organism. C. albicans was the only organism cultured from two bronchial lavage specimens. Total serum IgE was elevated to 5745 ng/ml and decreased rapidly with corticosteroid therapy. Serologic studies were not consistent with allergic bronchopulmonary aspergillosis. Serum IgE to C. albicans, measured by ELISA after adsorption of IgG from the serum samples by incubation with staphylococcal protein A, was found to be 575% to 650% above control values. The serum IgE antibody activity against Candida decreased with clinical improvement after corticosteroid therapy.
本文描述了一名患有符合变应性支气管肺念珠菌病的患者。该患者患有哮喘，曾三次出现肺不张性肺部浸润，对白色念珠菌提取物的即刻皮肤反应性低至10(-7)（重量/体积），且对该菌有沉淀抗体。白色念珠菌是从两份支气管灌洗标本中培养出的唯一菌种。血清总IgE升高至5745 ng/ml，并在皮质类固醇治疗后迅速下降。血清学研究不符合变应性支气管肺曲霉病。通过用葡萄球菌蛋白A孵育从血清样本中吸附IgG后，用ELISA法检测的血清抗白色念珠菌IgE比对照值高出575%至650%。皮质类固醇治疗后，随着临床症状改善，血清抗念珠菌IgE抗体活性降低。
