Salhi Salma, Oueslati Ibtissem, Ayari Sabrina, Kamoun Elyes, Yazidi Meriem, Chihaoui Melika
Department of Endocrinology, Faculty of Medicine La Rabta University Hospital, University of Tunis-El Manar Tunis Tunisia.
Clin Case Rep. 2023 Mar 15;11(3):e7085. doi: 10.1002/ccr3.7085. eCollection 2023 Mar.
A 48-year-old woman with a history of primary hypothyroidism, presented with compressive symptoms secondary to a rapid enlargement of a preexisting goiter. She had no clinical signs of hypocalcemia. Biological tests revealed hypoparathyroidism. Cervicothoracic computed tomography scan showed a heterogeneous compressive goiter. The patient was treated with levothyroxine, calcium, and alfacalcidol. A total thyroidectomy was not performed because of the hard adhesion to neighboring structures. Histopathological examination of the thyroid biopsy was consistent with the diagnosis of Riedel's thyroiditis (RT). The patient was treated with glucocorticoids. The outcome was marked by the resolution of compressive symptoms and the decrease of the thyroid gland volume. Serum calcium and parathyroid hormone levels reached normal ranges after the discontinuation of vitaminocalcic supplementation. Hypoparathyroidism may be clinically asymptomatic in a patient with RT as in our case. Early administration of glucocorticoids may be effective in reducing the fibrosclerotic process and lead to the recovery of parathyroid dysfunction.
一名48岁有原发性甲状腺功能减退病史的女性,因既往存在的甲状腺肿迅速增大出现压迫症状前来就诊。她没有低钙血症的临床体征。生物学检查显示甲状旁腺功能减退。颈胸计算机断层扫描显示甲状腺肿不均匀压迫。患者接受左甲状腺素、钙剂和阿法骨化醇治疗。由于与邻近结构粘连紧密,未进行甲状腺全切除术。甲状腺活检的组织病理学检查结果与里德尔甲状腺炎(RT)的诊断一致。患者接受糖皮质激素治疗。结果表现为压迫症状缓解和甲状腺体积减小。停用维生素D和钙剂补充后,血清钙和甲状旁腺激素水平恢复正常范围。如我们的病例所示,RT患者的甲状旁腺功能减退在临床上可能无症状。早期给予糖皮质激素可能有效减轻纤维硬化过程并导致甲状旁腺功能障碍恢复。