Institute of Microelectronics of the Chinese Academy of Sciences, Beijing, 100029, China.
University of Chinese Academy of Sciences, Beijing, 100049, China.
Analyst. 2023 Apr 11;148(8):1672-1681. doi: 10.1039/d3an00028a.
With the development of advanced nanofabrication techniques over the past decades, different nanostructure-based plasmonic fiber-optic sensors have been developed and have presented a low limit of detection for various biomolecules. However, owing to both the dependence on complex equipment and the trade-off between the fabrication cost and sensing performance, nanostructured plasmonic fiber-optic sensors are rarely used outside laboratories. To facilitate wider application of the plasmonic fiber-optic sensors, a parylene-mediated hybrid plasmonic-photonic cavity-based sensor was developed. Compared with a similar plasmonic sensor which only works in the plasmonic mode, the proposed hybrid sensor shows a higher reproducibility (CV < 2.5%) due to its resistance to fabrication variations. Meanwhile, a self-referenced detection mechanism and a novel miniaturized system were developed to adapt to the hybrid resonance sensor. The entire system only has a weight of 263 g, and a size of 12 cm × 10 cm × 8 cm, and is especially suitable for outdoor applications in a handheld manner. In experiments, a high refractive index sensitivity of 3.148 RIU and real-time biomolecule monitoring at nanomolar concentrations were achieved by the proposed system, further confirming the potential of the miniaturized system as a candidate for point-of-care health diagnostics outside laboratories.
在过去几十年中，随着先进的纳米制造技术的发展，已经开发出了基于不同纳米结构的等离子体光纤传感器，并为各种生物分子提供了低检测极限。然而，由于对复杂设备的依赖以及制造成本和传感性能之间的权衡，纳米结构等离子体光纤传感器很少在实验室之外使用。为了促进等离子体光纤传感器的更广泛应用，开发了一种基于派瑞林介导的混合等离子体-光子腔传感器。与仅在等离子体模式下工作的类似等离子体传感器相比，由于其对制造变化的抵抗力，所提出的混合传感器具有更高的重现性（CV<2.5%）。同时，开发了一种自参考检测机制和一种新颖的小型化系统，以适应混合共振传感器。整个系统的重量仅为 263 克，尺寸为 12 厘米×10 厘米×8 厘米，特别适合以手持式方式在户外应用。在实验中，所提出的系统实现了 3.148 RIU 的高折射率灵敏度和纳摩尔浓度的实时生物分子监测，进一步证实了该小型化系统作为实验室外即时医疗诊断候选者的潜力。
